ID   PEX5_CHICK              Reviewed;         645 AA.
AC   Q5ZMQ9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Peroxisomal targeting signal 1 receptor;
DE            Short=PTS1 receptor;
DE            Short=PTS1R;
DE   AltName: Full=PTS1-BP;
DE   AltName: Full=Peroxin-5;
DE   AltName: Full=Peroxisomal C-terminal targeting signal import receptor;
DE   AltName: Full=Peroxisome receptor 1;
GN   Name=PEX5; ORFNames=RCJMB04_1g17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
CC       targeting signal (SKL-type) and plays an essential role in peroxisomal
CC       protein import. {ECO:0000250|UniProtKB:Q920N5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q920N5}.
CC       Peroxisome membrane {ECO:0000250|UniProtKB:Q920N5}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:Q920N5}. Note=Its distribution appears
CC       to be dynamic. It is probably a cycling receptor found mainly in the
CC       cytoplasm and as well associated to the peroxisomal membrane through a
CC       docking factor (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC       family. {ECO:0000305}.
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DR   EMBL; AJ719325; CAG30984.1; -; mRNA.
DR   RefSeq; NP_001012836.1; NM_001012818.2.
DR   AlphaFoldDB; Q5ZMQ9; -.
DR   SMR; Q5ZMQ9; -.
DR   STRING; 9031.ENSGALP00000023615; -.
DR   PaxDb; Q5ZMQ9; -.
DR   GeneID; 418299; -.
DR   KEGG; gga:418299; -.
DR   CTD; 5830; -.
DR   VEuPathDB; HostDB:geneid_418299; -.
DR   eggNOG; KOG1125; Eukaryota.
DR   InParanoid; Q5ZMQ9; -.
DR   OrthoDB; 588648at2759; -.
DR   PhylomeDB; Q5ZMQ9; -.
DR   PRO; PR:Q5ZMQ9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; IBA:GO_Central.
DR   GO; GO:0016560; P:protein import into peroxisome matrix, docking; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR024111; PEX5/PEX5L.
DR   InterPro; IPR024113; PEX5_animals.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR10130; PTHR10130; 1.
DR   PANTHER; PTHR10130:SF2; PTHR10130:SF2; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Peroxisome; Protein transport; Reference proteome;
KW   Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation.
FT   CHAIN           1..645
FT                   /note="Peroxisomal targeting signal 1 receptor"
FT                   /id="PRO_0000284882"
FT   REPEAT          340..373
FT                   /note="TPR 1"
FT   REPEAT          375..407
FT                   /note="TPR 2"
FT   REPEAT          408..441
FT                   /note="TPR 3"
FT   REPEAT          459..491
FT                   /note="TPR 4"
FT   REPEAT          494..527
FT                   /note="TPR 5"
FT   REPEAT          529..561
FT                   /note="TPR 6"
FT   REPEAT          563..595
FT                   /note="TPR 7"
FT   CROSSLNK        11
FT                   /note="Glycyl cysteine thioester (Cys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   645 AA;  71791 MW;  71CDB78A8140B9DE CRC64;
     MAMRELVEPE CGGSNPLLKL AGHFTQDKAL RQEGLQGSLG WPPGAAGAAA VSKPLGVASE
     DELVGEFLQG QNAPLLSHAP QTLRWMTCWL RCKRLNSPAF RQAPQRAPGV AALALSENWT
     QEFLAAADTA GDVSSDYNEA DWSQEFIAEV TDPLSVSPAK WAEEYLEQSE EKLWLGESED
     QSLADKWYEE YQPEDDLKKT ASDFLSKVDD PKLNSSEFLK FVRQIGDGRV SIEANQVTHR
     DQDQAEQWAT EFMQQQGSSD AWVDQFARSG NLSALDTEFE QAKTAVESDV DFWDKLQAEW
     EEMAKRDAEA HPWLTDYDDL SSSSYDKGYQ FEEDNPMRDH PDAFEEGRKR LEEGDLPNAV
     LLFEAAVQQK PDHMEAWQYL GTTQAENEQE LLAISALRRC LELQPGNLTA LMALAVSFTN
     ESLQKQACET LRDWLHHKPA YAHLLEKAPE ENASETNLGT SKRVLGSLLS DSLFVEVKEL
     FLAAVRSNPS TVDPDVQCGL GVLFNLSGEY EKAVDCFSAA LSVRPNDHLL WNKLGATLAN
     GNRSEEAVAA YRRALELQPG YIRSRYNLGI SCINLGAHRE AVEHFLEALH MQQKSRGPRG
     QQGAMSDNIW STLRMALSML GQSDLYGAAD AHDLPTLLQA FGLQQ