PEX5_DICDI
ID PEX5_DICDI Reviewed; 641 AA.
AC Q54MD1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Peroxisomal targeting signal 1 receptor;
DE Short=PTS1 receptor;
DE Short=PTS1R;
DE AltName: Full=Peroxin-5;
GN Name=pex5; ORFNames=DDB_G0286033;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
CC targeting signal (SKL-type) and plays an essential role in peroxisomal
CC protein import. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000305}.
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DR EMBL; AAFI02000085; EAL64395.1; -; Genomic_DNA.
DR RefSeq; XP_637903.1; XM_632811.1.
DR AlphaFoldDB; Q54MD1; -.
DR SMR; Q54MD1; -.
DR STRING; 44689.DDB0238048; -.
DR PaxDb; Q54MD1; -.
DR EnsemblProtists; EAL64395; EAL64395; DDB_G0286033.
DR GeneID; 8625414; -.
DR KEGG; ddi:DDB_G0286033; -.
DR dictyBase; DDB_G0286033; pex5.
DR eggNOG; KOG1125; Eukaryota.
DR HOGENOM; CLU_013516_4_0_1; -.
DR InParanoid; Q54MD1; -.
DR OMA; LLYNMSY; -.
DR PhylomeDB; Q54MD1; -.
DR Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-DDI-9033241; Peroxisomal protein import.
DR Reactome; R-DDI-9664873; Pexophagy.
DR PRO; PR:Q54MD1; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; ISS:dictyBase.
DR GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; IBA:GO_Central.
DR GO; GO:0000268; F:peroxisome targeting sequence binding; ISS:dictyBase.
DR GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IBA:GO_Central.
DR GO; GO:0006625; P:protein targeting to peroxisome; ISS:dictyBase.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130; PTHR10130; 2.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Membrane; Peroxisome; Protein transport; Reference proteome;
KW Repeat; Thioester bond; TPR repeat; Transport; Ubl conjugation.
FT CHAIN 1..641
FT /note="Peroxisomal targeting signal 1 receptor"
FT /id="PRO_0000330930"
FT REPEAT 359..392
FT /note="TPR 1"
FT REPEAT 393..426
FT /note="TPR 2"
FT REPEAT 427..460
FT /note="TPR 3"
FT REPEAT 503..536
FT /note="TPR 4"
FT REPEAT 538..570
FT /note="TPR 5"
FT REPEAT 571..604
FT /note="TPR 6"
FT CROSSLNK 12
FT /note="Glycyl cysteine thioester (Cys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000255"
SQ SEQUENCE 641 AA; 74586 MW; F06F9D55568F1BCD CRC64;
MSVFRDLVEG ECSEPNALGN FVQHFTNERS YHDKFEDHGK NEFYDSLYRH EEEYNEQRHL
DSIFDGEGQE DDIHLMMDRH LNLRDGPREH KELPLSNVES DLQFLFQDFI NSTRAGQLFH
PSSLNHLPLT FEDKSKIKNR SSIMLKHFSN GESEQFEEDQ LNRMLDSLGI EVGDDFDQVW
DSQPHHTTTT TTTTTTTTTG QYDQYQKYVN DLPEEYEDYE QHQQELFDDG DLEDYELDEE
WDKGDDFHPY DSAWTESDRS VEAAWDETAR RTISDITRPI TQINDPKLKK SNFMKFMNQL
NSGEASIVGS DVVHNPDFKR QEEYQQQADQ WTEDYNDFHE HIPQHRIQEY QFSIQEARDS
DTLERGMGLF NEGHLSDSII ALESEVKRNP ENAMAWMYLG IAHAENDQDS QATTCLIKSL
QIDPTNSKAR LALAVSHTND YQKERALDTL EEWLQRTPEY TALYKQFKGS VDPNSFLDTW
SRHEFTTNLF IEAARSRPSN PDPEVQTALG LLYNMSYDYD KAVDCFKAAL QNSPTDYQLW
NKLGATLANS NRSQEALGAY FKALEHKPSY VRARSNLGIS YLSLNMFQES ATTFLGAIAI
HPAPNIWDNL KMVFRLMNRE DLVQKADLRD VNAFLDEFQF M
