ID   PEX6_DICDI              Reviewed;        1201 AA.
AC   Q54CS8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Peroxisomal biogenesis factor 6;
DE   AltName: Full=Peroxin-6;
GN   Name=pex6; ORFNames=DDB_G0292788;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for biogenesis of peroxisomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; AAFI02000196; EAL61068.1; -; Genomic_DNA.
DR   RefSeq; XP_629463.1; XM_629461.1.
DR   AlphaFoldDB; Q54CS8; -.
DR   SMR; Q54CS8; -.
DR   STRING; 44689.DDB0238049; -.
DR   PaxDb; Q54CS8; -.
DR   PRIDE; Q54CS8; -.
DR   EnsemblProtists; EAL61068; EAL61068; DDB_G0292788.
DR   GeneID; 8628853; -.
DR   KEGG; ddi:DDB_G0292788; -.
DR   dictyBase; DDB_G0292788; pex6.
DR   eggNOG; KOG0736; Eukaryota.
DR   HOGENOM; CLU_000688_0_8_1; -.
DR   InParanoid; Q54CS8; -.
DR   OMA; YYHKVQK; -.
DR   PhylomeDB; Q54CS8; -.
DR   PRO; PR:Q54CS8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Membrane; Nucleotide-binding; Peroxisome;
KW   Peroxisome biogenesis; Reference proteome.
FT   CHAIN           1..1201
FT                   /note="Peroxisomal biogenesis factor 6"
FT                   /id="PRO_0000365734"
FT   REGION          247..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..280
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         959..966
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1201 AA;  137009 MW;  D43E658EC94C9F79 CRC64;
     MIGLFKDEWF NISILNDNLF LKRYCYESNN NNNNNNTLYT IIVPFDKSIN PSQFDPSTIN
     DYFIFLYKNT KKINLNSINK LQYKSNKKEI LVSFDITYIH NSNNNNNNNN NKLKSVLISN
     SCSKKLNLFN NDIVHLKPIK KKLTVLQRVV LLANDNESFI ESSNPSESSS STTTINSKYL
     VNEEFRNYLV ENSILFQSPN NIVIENHQKH KSFSYKVLEC FPLLQGTVSN STTIIIISPD
     DKILNTLPSN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NKEEEVEEEE VEVEEEEKDN
     KLKLNNNLRL SNFIIHPIIN ISNNTTTKNE DIGDSNNLFH FTPSSKGILS NNKKFINISQ
     LKSIPTEIDF EFDISKEYDY LVDCLVSLNT LKSLNLFNGS WIKIKNITNN NNNNNNKEYE
     IAIRIFSITS SLKLKDQVLY LPPISIFNLN IDYKNFLKLS NYEIISNQFE LILLKSNKPN
     INNNNNNDSF PINYPTANRI KISRIKNQNS SGYKSYSHQL EKYFQKKRLL KQNDIIVIST
     KVNNEEELIN SNNSNNNNNY NNNNNNNNNN NLVYFKVEII LCNQFENING NQIYLIDKNT
     TSIIQEGSSN SMVPSKIESF YWRGGDQEES KDNSMVPLEL IYENEFKTIV DLISPFLMGD
     KFSFDFNCTL LLNGPQGVGK RTLLNRVAKQ MGIHVYEVDC YKLYDFVESK KDWNIRNVLE
     QASNSTPTLL ILKNFEVLEQ TAQSMQQEKK ESNLSQTLIN ILKDINDSNT SNINSNKYPL
     IITVTVNSMD ELSNKVRNWF KHEITLNSPD ENQRFKILKY LTKNLPIDIG NTVSIKNLSI
     RTASFLNSNL RALIQRSSIN ALKRVLSIQQ MMNDEIKPIE IYNCGFLVMG DDIQKSLSEM
     QEYQSSSIGA PKIPNVSWDD VGGLANVKSE IMDTIQLPLE HPHLFASGIG KRSGILLFGP
     PGTGKTLLAK AIATECSLNF LSVKGPELIN MYIGESEKNI REIFNKARQA KPCVIFFDEL
     DSLAPSRGNG ADSGGVMDRV VSQLLAELDG MQKSSDVFII GATNRPDLLD SSLMRPGRLD
     RLLYLGISSE KENQFKILQA LTRKFNLADD VDLRKVVENC PMNLTGADFY ALASDAMSNA
     FHERITASIN GEINEEEQNQ KLIVYQNHFI KAVNSLVPSV SLDELEYYHK VQKQFSGNNK
     S