ID   PEX6_NEUCR              Reviewed;        1381 AA.
AC   Q7SGP2;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Peroxisomal biogenesis factor 6;
DE   AltName: Full=Peroxin-6;
GN   Name=pex-6; ORFNames=NCU08373;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA36040.1; -; Genomic_DNA.
DR   RefSeq; XP_965276.1; XM_960183.2.
DR   AlphaFoldDB; Q7SGP2; -.
DR   SMR; Q7SGP2; -.
DR   STRING; 5141.EFNCRP00000006478; -.
DR   PRIDE; Q7SGP2; -.
DR   EnsemblFungi; EAA36040; EAA36040; NCU08373.
DR   GeneID; 3881433; -.
DR   KEGG; ncr:NCU08373; -.
DR   VEuPathDB; FungiDB:NCU08373; -.
DR   HOGENOM; CLU_000688_0_2_1; -.
DR   InParanoid; Q7SGP2; -.
DR   OMA; MVQAGSE; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Peroxisome biogenesis; Reference proteome.
FT   CHAIN           1..1381
FT                   /note="Peroxisomal biogenesis factor 6"
FT                   /id="PRO_0000084615"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1294..1381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..315
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1334..1348
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1031..1038
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1381 AA;  148374 MW;  2600C6CF10B2EE12 CRC64;
     MTAPNSTPAS SRKRVRRRRQ DKPALSAKLV LDAHVKGDVG VIATDLFADL FPHLWANGDS
     QDTVHVAIAP WAPSQTPEAN NWSIVPVIRS STVAPSTVQF SPSSLALQSF ATHLQQAAPS
     KLSGHNKGGI EILILDVSPI ELDTVFVNLD GELAKRLEDG EGTFFREHPV NGKGKARADA
     TPEEHLTAAL RTALGTLKIV HSGDFFPLPL PPHPVTHQPP NPGRITLCEP VAQGILAPTT
     KIIVSRVRTS KTKRSSASGQ QQGRKLNGVA EDDEDAYFSA AEEDRDSKTN AQTAETDADD
     TEFEPQAGED EDNLSDDSLD EIISLQVPTL PTTVTGQSTI GTGTPTMLRG RKTNGPGSVI
     SSYTATTARP DRPRGRLFKA HGLMKPIPPD LLHPKPTPED DEEACIYVDM RDLTRVGCFS
     GDWIRVEAAS EPPSNGLGAF GLGSFVEQEA DEINWRPARV FGLPEGYSSR SATRSHHSRH
     DSRNSSFFEA QSQKSNPPAY TSPILLANLD NPPYLRLSPI KRPSSSIIKG VAAQSKTSST
     LKPPFAREVI LQHVRTPTAV ERDVQSAVMA GLKHYFERRL RVLRTGDLIA VPIDTQLGKA
     LQESTIPGED SAIDEVLGLI AATRPGQSLH YDDVAWFRVG HVQAMKQDTT EAVDGEEAED
     LWGGIACVDI SLTHLEQSGS VTGRIPGTIS NSWQYYLGIR KLPKHQQNPG LPAQLQTLEP
     EKQYVSSLRR KLRELMAAAT SKPALHLNLP PLAILLVSTQ RHIGKAATAM QACSDIGLHT
     FAIDAYDIVN DGGGGGGSDV KTAGFLTSRA ERAMSCGPES CVLLVRHIEA LTADRMVSSI
     KEILADARVL IATTTEVEKV PDGIRALFTH ELEMSAPDEQ EREGILSSIL ADRGIGLDHG
     VDLSGIALKT AALVAGDLVD VVDRALVAQR SRLEKLTAKA TGSITFRDVQ LAGGPAASGL
     TKQDFELAVD AARKNFADSI GAPKIPNVTW DDVGGLGNVK DAITETIQLP LERPELFAKG
     MKKRSGILFY GPPGTGKTLL AKAIATEYSL NFFSVKGPEL LNMYIGESEA NVRRVFQRAR
     DARPCVVFFD ELDSVAPKRG NQGDSGGVMD RIVSQLLAEL DGMSGGEGGG GGVFVIGATN
     RPDLLDPALL RPGRFDKMLY LGVSDTHDKQ VTIMEALTRK FTLHPTVSLR SVAERLPFTY
     TGADFYALCS DAMLKAVTRQ ATLVDTKIRE LNAAAGPEGK QISTAYFFDH YATKEDISVM
     VTEQDFLDAH RELVPSVSAG ELEHYEQVRA MFEGAKDKDK KKEGAGGDGN GVDGLESGNR
     NGMLAITMGD DGAGAESTKK DGKGKGKAAD NEVNGAGEGK GKEGVSPFQE SGGDEDEGLY
     D