ID   PEX6_PICPA              Reviewed;        1165 AA.
AC   P33289;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Peroxisomal biogenesis factor 6;
DE   AltName: Full=Peroxin-6;
DE   AltName: Full=Peroxisome biosynthesis protein PAS5;
GN   Name=PEX6; Synonyms=PAS5;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76273 / CBS 7435 / CECT 11407 / NRRL Y-11430;
RX   PubMed=8227124; DOI=10.1083/jcb.123.3.535;
RA   Spong A.P., Subramani S.;
RT   "Cloning and characterization of PAS5: a gene required for peroxisome
RT   biogenesis in the methylotrophic yeast Pichia pastoris.";
RL   J. Cell Biol. 123:535-548(1993).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. Necessary for matrix
CC       peroxisomal proteins import. Essential for growth on oleic acid and
CC       methanol as sole carbon source.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=It may be associated with the
CC       cytoskeleton or it may be cytoplasmic.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z22556; CAA80278.1; -; Genomic_DNA.
DR   PIR; A48667; A48667.
DR   AlphaFoldDB; P33289; -.
DR   SMR; P33289; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Peroxisome biogenesis.
FT   CHAIN           1..1165
FT                   /note="Peroxisomal biogenesis factor 6"
FT                   /id="PRO_0000084618"
FT   BINDING         859..866
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1165 AA;  129137 MW;  DEA192C1D5CA46EA CRC64;
     MPGITETSQV TGPVLAHVIV TEDPYDASER AFLSTDLYEL LFEDYANGSK SGLTLISIQL
     MGSSLFNEFQ TFKVYESEEQ LPPNTVNLCN MGNIIDYSSD FTVDSGYVAR VDSLVKLDTV
     IISVLPEVYS LASQSQHQLV DILGGNDQHT VIRQGDYNKD INGKISLCEP TDQGFLESTT
     KIIVVKENSL NLPLLDQSQD GSLNYEENVK MNLEHSISNY FSLNSLDPEN QITTTGVEFS
     VKCLDSPISV RKTAKSISVA HDSEDESSPK LVEEDISNED TLLYAFCKTT ELAKIGCLSG
     DIVKMKSGQC QCTTFECNCE SCPVQYRYIR IHAFTDPNTY EKGCIYLNPI LSFNLNNPKI
     VKLCPISIPD KRFELQGFHF SKFIPLAKQV TIARVSSPVT LDRTLQTLFL TNLKTYFESG
     RKVLSKDQLI PIPVDTLLAK SIFSTYEKLG VDDSQFPTVI PEGKPDAIAW FKVTEVSGEL
     ADSASQQFII DPLKTKMMQS GVVSCSPPKN SQHCNWANYL GCGQMFSFPN VSGVTTSTFE
     YAKTLRKLIK ATIDPSRLVN LQTTVLLSSL SRAIGKSLLV HSLALECGVH LVEIDGYEVL
     NPSSESKTIG TIRGKLDRVV EGCTPLIVFI KHIEALTKKS EQQQKDSLAV KINELIDEYT
     AKPGVLFVAS TNDSDNLSDE LRAKFKFEIV LGVPSEQERT LIFKYLIDFD QKTTPKVTEG
     TRELSFAPRN DLSLSSLSLQ SAGLTPRDLI SIVENAKTLA VDRVESLAKH HNVSFENMVY
     SSGGYIKFTP EDVEKSINTA RNKFSDSIGA PRIPNVKWED VGGLDVVKDE ILDTIDMPMK
     HPELFSNGIK KRSGILFYGP PGTGKTLLAK AIATNFALNF FSVKGPELLN MYIGESEANV
     RKVFQRARDA KPCVVFFDEL DSVAPKRGNQ GDSEGVMDRI VSQLLAELDG MSGGDGGDGV
     FVVGATNRPD LLDEALLRPG RFDKMLYLGV SDTHEKQSKI MEALSRKFHL HPSVDLDKVA
     ESCPFTFTGA DFYALCSDAM LNAMTRIANT VDEKIKRYNE ELPEKSQVST RWWFDNVATK
     EDIDVLVTLE DFDKSRKELV PSVSAEELDH YLRVRQNFEG GKEKKVVQEN GQTEHFSNGS
     ANNHITFGDE QVVEAIDENG NSIIA