ID   PEX6_YARLI              Reviewed;        1024 AA.
AC   P36966; Q6CBH6;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Peroxisomal biogenesis factor 6;
DE   AltName: Full=Peroxin-6;
DE   AltName: Full=Peroxisome biosynthesis protein PAY4;
GN   Name=PEX6; Synonyms=PAY4; OrderedLocusNames=YALI0C18689g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8276851; DOI=10.1016/s0021-9258(17)42385-4;
RA   Nuttley W.M., Brade A.M., Eitzen G.A., Veenhuis M., Aitchison J.D.,
RA   Szilard R.K., Glover J.R., Rachubinski R.A.;
RT   "PAY4, a gene required for peroxisome assembly in the yeast Yarrowia
RT   lipolytica, encodes a novel member of a family of putative ATPases.";
RL   J. Biol. Chem. 269:556-566(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; L23858; AAA16622.1; -; Unassigned_DNA.
DR   EMBL; CR382129; CAG82306.1; -; Genomic_DNA.
DR   PIR; A53121; A53121.
DR   RefSeq; XP_501986.1; XM_501986.1.
DR   AlphaFoldDB; P36966; -.
DR   SMR; P36966; -.
DR   STRING; 4952.CAG82306; -.
DR   EnsemblFungi; CAG82306; CAG82306; YALI0_C18689g.
DR   GeneID; 2909504; -.
DR   KEGG; yli:YALI0C18689g; -.
DR   VEuPathDB; FungiDB:YALI0_C18689g; -.
DR   HOGENOM; CLU_000688_0_0_1; -.
DR   InParanoid; P36966; -.
DR   OMA; DSMLNAM; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:1904949; C:ATPase complex; IEA:EnsemblFungi.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:EnsemblFungi.
DR   GO; GO:0043335; P:protein unfolding; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Peroxisome biogenesis;
KW   Reference proteome.
FT   CHAIN           1..1024
FT                   /note="Peroxisomal biogenesis factor 6"
FT                   /id="PRO_0000084620"
FT   BINDING         759..766
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        670..673
FT                   /note="DSDT -> ERPIA (in Ref. 1; AAA16622)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        828
FT                   /note="G -> R (in Ref. 1; AAA16622)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1024 AA;  112011 MW;  1C089C8C1A25A032 CRC64;
     MPSISHKPIT AKLVAAPDAT KLELSSYLYQ QLFSDKPAEP YVAFEAPGIK WALYPASEDR
     SLPQYTCKAD IRHVAGSLKK FMPVVLKRVN PVTIEHAIVT VPASQYETLN TPEQVLKALE
     PQLDKDRPVI RQGDVLLNGC RVRLCEPVNQ GKVVKGTTKL TVAKEQETIQ PADEAADVAF
     DIAEFLDFDT SVAKTRESTN LQVAPLEGAI PTPLSDRFDD CESRGFVKSE TMSKLGVFSG
     DIVSIKTKNG AERVLRLFAY PEPNTVKYDV VYVSPILYHN IGDKEIEVTP NGETHKSVGE
     ALDSVLEAAE EVKLARVLGP TTTDRTFQTA YHAGLQAYFK PVKRAVRVGD LIPIPFDSIL
     ARTIGEDPEM SHIPLEALAV KPDSVAWFQV TSLNGSEDPA SKQYLVDSSQ TKLIEGGTTS
     SAVIPTSVPW REYLGLDTLP KFGSEFAYAD KIRNLVQIST SALSHAKLNT SVLLHSAKRG
     VGKSTVLRSV AAQCGISVFE ISCFGLIGDN EAQTLGTLRA KLDRAYGCSP CVVVLQHLES
     IAKKSDQDGK DEGIVSKLVD VLADYSGHGV LLAATSNDPD KISEAIRSRF QFEIEIGVPS
     EPQRRQIFSH LTKSGPGGDS IRNAPISLRS DVSVENLALQ SAGLTPPDLT AIVQTTRLRA
     IDRLNKLTKD SDTTLDDLLT LSHGTLQLTP SDFDDAIADA RQKYSDSIGA PRIPNVGWDD
     VGGMEGVKKD ILDTIETPLK YPHWFSDGVK KRSGILFYGP PGTGKTLLAK AIATTFSLNF
     FSVKGPELLN MYIGESEANV RRVFQKARDA KPCVVFFDEL DSVAPQRGNQ GDSGGVMDRI
     VSQLLAELDG MSTAGGEGVF VVGATNRPDL LDEALLRPGR FDKMLYLGIS DTHEKQQTIM
     EALTRKFRLA ADVSLEAISK RCPFTFTGAD FYALCSDAML NAMTRTANEV DAKIKLLNKN
     REEAGEEPVS IRWWFDHEAT KSDIEVEVAQ QDFEKAKDEL SPSVSAEELQ HYLKLRQQFE
     GGKK