ID   PEX7_CRIGR              Reviewed;         318 AA.
AC   Q8R537; P83383;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Peroxisomal targeting signal 2 receptor;
DE            Short=PTS2 receptor;
DE   AltName: Full=Peroxin-7;
GN   Name=PEX7;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000312|EMBL:BAB86040.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PEX5, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=11756410; DOI=10.1074/jbc.m108635200;
RA   Mukai S., Ghaedi K., Fujiki Y.;
RT   "Intracellular localization, function, and dysfunction of the peroxisome-
RT   targeting signal type 2 receptor, Pex7p, in mammalian cells.";
RL   J. Biol. Chem. 277:9548-9561(2002).
RN   [2]
RP   INTERACTION WITH VWA8.
RX   PubMed=30204880; DOI=10.1093/jb/mvy073;
RA   Niwa H., Miyauchi-Nanri Y., Okumoto K., Mukai S., Noi K., Ogura T.,
RA   Fujiki Y.;
RT   "A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel
RT   dynein-type AAA+ protein.";
RL   J. Biochem. 164:437-447(2018).
CC   -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC       signal and plays an essential role in peroxisomal protein import.
CC       {ECO:0000269|PubMed:11756410}.
CC   -!- SUBUNIT: Interacts with PEX5 (PubMed:11756410). Interacts with VWA8
CC       (PubMed:30204880). {ECO:0000269|PubMed:11756410,
CC       ECO:0000269|PubMed:30204880}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11756410}.
CC       Cytoplasm {ECO:0000269|PubMed:11756410}.
CC   -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
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DR   EMBL; AB042621; BAB86040.1; -; mRNA.
DR   RefSeq; NP_001231782.1; NM_001244853.1.
DR   AlphaFoldDB; Q8R537; -.
DR   SMR; Q8R537; -.
DR   STRING; 10029.NP_001231782.1; -.
DR   Ensembl; ENSCGRT00001005400; ENSCGRP00001003700; ENSCGRG00001004544.
DR   GeneID; 100736556; -.
DR   KEGG; cge:100736556; -.
DR   CTD; 5191; -.
DR   eggNOG; KOG0277; Eukaryota.
DR   GeneTree; ENSGT00940000157264; -.
DR   OrthoDB; 793152at2759; -.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005782; C:peroxisomal matrix; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
DR   GO; GO:0008611; P:ether lipid biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:Ensembl.
DR   GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR044536; PEX7.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR46027; PTHR46027; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Peroxisome; Protein transport; Repeat; Transport; WD repeat.
FT   CHAIN           1..318
FT                   /note="Peroxisomal targeting signal 2 receptor"
FT                   /id="PRO_0000051115"
FT   REPEAT          60..100
FT                   /note="WD 1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          104..145
FT                   /note="WD 2"
FT                   /evidence="ECO:0000305"
FT   REPEAT          148..188
FT                   /note="WD 3"
FT                   /evidence="ECO:0000305"
FT   REPEAT          191..231
FT                   /note="WD 4"
FT                   /evidence="ECO:0000305"
FT   REPEAT          235..275
FT                   /note="WD 5"
FT                   /evidence="ECO:0000305"
FT   REPEAT          279..317
FT                   /note="WD 6"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   318 AA;  35460 MW;  511501A4D0C6DB2E CRC64;
     MSAARTLRVP GRHGYAAEFS PYLPGRLACA AAQHYGIAGC GTLIILDQNQ SGLQIFRSFD
     WSDGLFDVTW SEDNEHVLVT CSGDGSLQLW DTAKATGPLQ VYKEHTQEVY SVDWSQTRGE
     QLVVSGSWDQ TVKVWDPTVG NSLCTFRGHE SVIYSTIWSP HIPGCFASAS GDQTLRIWDV
     KTAGVRIVIP AHQTEILSCD WCKYNENLVV TGAVDCSLRG WDLRNVRQPV FELLGHTYAI
     RRVKFSPFHA SVLASCSYDF TVRFWNFSKP DPLLETVEHH TEFTCGLDLS LQSPTEVADC
     SWDETIKIYD PVCLTVPG