ID   PEX7_DICDI              Reviewed;         316 AA.
AC   Q54WA3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Peroxisomal targeting signal 2 receptor;
DE            Short=PTS2 receptor;
DE   AltName: Full=Peroxin-7;
GN   Name=pex7; ORFNames=DDB_G0279801;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC       signal and plays an essential role in peroxisomal protein import.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
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DR   EMBL; AAFI02000033; EAL67514.1; -; Genomic_DNA.
DR   RefSeq; XP_641489.1; XM_636397.1.
DR   AlphaFoldDB; Q54WA3; -.
DR   SMR; Q54WA3; -.
DR   STRING; 44689.DDB0233068; -.
DR   PaxDb; Q54WA3; -.
DR   EnsemblProtists; EAL67514; EAL67514; DDB_G0279801.
DR   GeneID; 8622229; -.
DR   KEGG; ddi:DDB_G0279801; -.
DR   dictyBase; DDB_G0279801; pex7.
DR   eggNOG; KOG0277; Eukaryota.
DR   HOGENOM; CLU_046581_1_0_1; -.
DR   InParanoid; Q54WA3; -.
DR   OMA; EKWNYHT; -.
DR   PhylomeDB; Q54WA3; -.
DR   Reactome; R-DDI-9033241; Peroxisomal protein import.
DR   PRO; PR:Q54WA3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005782; C:peroxisomal matrix; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:dictyBase.
DR   GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; ISS:dictyBase.
DR   GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR044536; PEX7.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR46027; PTHR46027; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Peroxisome; Protein transport; Reference proteome; Repeat;
KW   Transport; WD repeat.
FT   CHAIN           1..316
FT                   /note="Peroxisomal targeting signal 2 receptor"
FT                   /id="PRO_0000371406"
FT   REPEAT          56..96
FT                   /note="WD 1"
FT   REPEAT          102..142
FT                   /note="WD 2"
FT   REPEAT          145..185
FT                   /note="WD 3"
FT   REPEAT          188..228
FT                   /note="WD 4"
FT   REPEAT          232..272
FT                   /note="WD 5"
FT   REPEAT          277..316
FT                   /note="WD 6"
SQ   SEQUENCE   316 AA;  36810 MW;  3199BCD1A04DF344 CRC64;
     MKRFHSHFNG YSVEFSPFEE QRLACVTSQH FGIIGNGRQY ILDVLDRDIG AFKTFDTRDG
     LYDCTWSEEN ECHVASSSGD GSIKIWDTQA PSGGRPIKSF EEHTKEVYSV DWNLVTKDTF
     ITGSWDQSIK IWNPRMDRSL KTFREHRYCI YSAIWSPRNA HLFASVSGDR TLKIWDSRDN
     RSLNTIKAHD HEILTCDWNK YNDKEVVTGS VDKTIRIWDI RYPDRPTTIL RGHTYAVRRI
     KCSPHSESML ASCSYDMSVI VWDRAREQDP IIARMDHHTE FVVGLDWNMF IDGQMASCSW
     DEQVCVWNLG RPGQFR