PEX7_MOUSE
ID PEX7_MOUSE Reviewed; 318 AA.
AC P97865; A2RSR2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Peroxisomal targeting signal 2 receptor;
DE Short=PTS2 receptor;
DE AltName: Full=Peroxin-7;
GN Name=Pex7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9090381; DOI=10.1038/ng0497-369;
RA Braverman N., Steel G., Obie C., Moser A., Moser H., Gould S.J., Valle D.;
RT "Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for
RT rhizomelic chondrodysplasia punctata.";
RL Nat. Genet. 15:369-376(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC signal and plays an essential role in peroxisomal protein import.
CC {ECO:0000250|UniProtKB:Q8R537}.
CC -!- SUBUNIT: Interacts with PEX5 and VWA8. {ECO:0000250|UniProtKB:Q8R537}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q8R537}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q8R537}.
CC -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
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DR EMBL; U69171; AAB49755.1; -; mRNA.
DR EMBL; BC132213; AAI32214.1; -; mRNA.
DR EMBL; BC132503; AAI32504.1; -; mRNA.
DR CCDS; CCDS23720.1; -.
DR RefSeq; NP_032848.1; NM_008822.2.
DR AlphaFoldDB; P97865; -.
DR SMR; P97865; -.
DR BioGRID; 202118; 12.
DR STRING; 10090.ENSMUSP00000020182; -.
DR iPTMnet; P97865; -.
DR PhosphoSitePlus; P97865; -.
DR EPD; P97865; -.
DR MaxQB; P97865; -.
DR PaxDb; P97865; -.
DR PRIDE; P97865; -.
DR ProteomicsDB; 288045; -.
DR Antibodypedia; 33017; 164 antibodies from 34 providers.
DR Ensembl; ENSMUST00000020182; ENSMUSP00000020182; ENSMUSG00000020003.
DR GeneID; 18634; -.
DR KEGG; mmu:18634; -.
DR UCSC; uc007enl.2; mouse.
DR CTD; 5191; -.
DR MGI; MGI:1321392; Pex7.
DR VEuPathDB; HostDB:ENSMUSG00000020003; -.
DR eggNOG; KOG0277; Eukaryota.
DR GeneTree; ENSGT00940000157264; -.
DR InParanoid; P97865; -.
DR OMA; EKWNYHT; -.
DR OrthoDB; 793152at2759; -.
DR PhylomeDB; P97865; -.
DR TreeFam; TF323220; -.
DR Reactome; R-MMU-9033241; Peroxisomal protein import.
DR BioGRID-ORCS; 18634; 6 hits in 71 CRISPR screens.
DR PRO; PR:P97865; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P97865; protein.
DR Bgee; ENSMUSG00000020003; Expressed in left lobe of liver and 255 other tissues.
DR ExpressionAtlas; P97865; baseline and differential.
DR Genevisible; P97865; MM.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005782; C:peroxisomal matrix; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0001958; P:endochondral ossification; IMP:MGI.
DR GO; GO:0008611; P:ether lipid biosynthetic process; ISO:MGI.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0007031; P:peroxisome organization; ISO:MGI.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IMP:MGI.
DR GO; GO:0006625; P:protein targeting to peroxisome; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR044536; PEX7.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46027; PTHR46027; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Peroxisome; Protein transport; Reference proteome; Repeat;
KW Transport; WD repeat.
FT CHAIN 1..318
FT /note="Peroxisomal targeting signal 2 receptor"
FT /id="PRO_0000051117"
FT REPEAT 60..91
FT /note="WD 1"
FT REPEAT 104..136
FT /note="WD 2"
FT REPEAT 148..179
FT /note="WD 3"
FT REPEAT 191..222
FT /note="WD 4"
FT REPEAT 235..266
FT /note="WD 5"
FT REPEAT 279..310
FT /note="WD 6"
SQ SEQUENCE 318 AA; 35502 MW; 7B7591FE8F715CFA CRC64;
MSAARTLRVP GRHGYAAEFS PYLPGRLACA AAQHYGIAGC GTLLVLDQNE SGLQIFRSFD
WNDGLFDVTW SENNEHVLVT CSGDGSLQLW DTAKATGPLQ VYKEHTQEVY SVDWSQTRGE
QLVVSGSWDQ TVKVWDPTVG NSLCTFRGHE SVIYSTIWSP HIPGCFASAS GDQTLRIWDV
KTTGVRIVIP AHQTEILSCD WCKYNENLVV TGAVDCSLRG WDLRNVRQPV FELLGHTYAI
RRVKFSPFHA SVLASCSYDF TVRFWNFSKP DPLLETVEHH TEFTCGLDLS LQSPTQVADC
SWDETIKIYD PVCLTVPG
