ID   PEX7_PICPA              Reviewed;         376 AA.
AC   O59894;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Peroxisomal targeting signal 2 receptor;
DE            Short=PTS2 receptor;
DE   AltName: Full=Peroxin-7;
GN   Name=PEX7;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PPY12;
RX   PubMed=9472033; DOI=10.1083/jcb.140.4.807;
RA   Elgersma Y., Elgersma-Hooisma M., Wenzel T., McCaffery J.M., Farquhar M.G.,
RA   Subramani S.;
RT   "A mobile PTS2 receptor for peroxisomal protein import in Pichia
RT   pastoris.";
RL   J. Cell Biol. 140:807-820(1998).
CC   -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC       signal and plays an essential role in peroxisomal protein import.
CC   -!- SUBUNIT: Interacts with PEX5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
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DR   EMBL; AF021797; AAC08303.1; -; Genomic_DNA.
DR   AlphaFoldDB; O59894; -.
DR   SMR; O59894; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; IEA:InterPro.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR044536; PEX7.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR46027; PTHR46027; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Peroxisome; Protein transport; Repeat; Transport; WD repeat.
FT   CHAIN           1..376
FT                   /note="Peroxisomal targeting signal 2 receptor"
FT                   /id="PRO_0000051118"
FT   REPEAT          58..98
FT                   /note="WD 1"
FT   REPEAT          102..142
FT                   /note="WD 2"
FT   REPEAT          182..222
FT                   /note="WD 3"
FT   REPEAT          226..267
FT                   /note="WD 4"
FT   REPEAT          279..319
FT                   /note="WD 5"
FT   REPEAT          339..375
FT                   /note="WD 6"
SQ   SEQUENCE   376 AA;  42422 MW;  3FE1279920E2CAA6 CRC64;
     MFKFQTNGFS GYAVRYSPFY DNKIAVATSA NYGLVGNGRL YVLSIMDDGN IITDISYDTQ
     DGLFGVAWSE TNENHVLTSS GDGCVSLFDT TLKDYPVMKF TEHQREVFSV DWSNIDKNLF
     CSASWDGSVK VWSPGSNRNT SLLTLRSLAS REEKTGRIEK PIPVVQPSQV PMSKTRPNIR
     NDNNDCVYDA KFSFHDPNII MSCNSDSHLQ LWDTRLPNPL FMDFVAHNGL EALSCDFNRY
     RPFVVASAGV DKLAKVWDTR MIQPNVHSRP PRALNKFMGH EFAIRKLAWS PHGPTQLLTC
     SYDMTVRVWN DSPSPTSRVG LLDGASQPHA PPCSKIFSAH TEFVMGCDWS LWGEPGWVVT
     TGWDEMVYVW NTQRLQ