ID   PEX7_SCHPO              Reviewed;         308 AA.
AC   P78798; A6X979; Q9HGQ4; Q9P7Q3;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 142.
DE   RecName: Full=Peroxisomal targeting signal 2 receptor;
DE            Short=PTS2 receptor;
DE   AltName: Full=Peroxin-7;
GN   Name=pex7; ORFNames=SPAC17D4.01, SPAC1834.12, SPAP17D4.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=PR745;
RX   PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA   Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT   "Identification of open reading frames in Schizosaccharomyces pombe
RT   cDNAs.";
RL   DNA Res. 4:363-369(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC       signal and plays an essential role in peroxisomal protein import.
CC   -!- SUBUNIT: Interacts with PEX5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Cytoplasm
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13809.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D89147; BAA13809.1; ALT_INIT; mRNA.
DR   EMBL; CU329670; CAO77648.1; -; Genomic_DNA.
DR   PIR; T42423; T42423.
DR   PIR; T50123; T50123.
DR   RefSeq; XP_001713109.1; XM_001713057.2.
DR   AlphaFoldDB; P78798; -.
DR   SMR; P78798; -.
DR   BioGRID; 858100; 3.
DR   STRING; 4896.SPAC17D4.01.1; -.
DR   SwissPalm; P78798; -.
DR   MaxQB; P78798; -.
DR   PaxDb; P78798; -.
DR   EnsemblFungi; SPAC17D4.01.1; SPAC17D4.01.1:pep; SPAC17D4.01.
DR   PomBase; SPAC17D4.01; pex7.
DR   VEuPathDB; FungiDB:SPAC17D4.01; -.
DR   eggNOG; KOG0277; Eukaryota.
DR   HOGENOM; CLU_046581_1_0_1; -.
DR   InParanoid; P78798; -.
DR   OMA; EKWNYHT; -.
DR   PhylomeDB; P78798; -.
DR   Reactome; R-SPO-9033241; Peroxisomal protein import.
DR   PRO; PR:P78798; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005782; C:peroxisomal matrix; ISO:PomBase.
DR   GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR   GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; IBA:GO_Central.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR044536; PEX7.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR46027; PTHR46027; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Peroxisome; Protein transport; Reference proteome; Repeat;
KW   Transport; WD repeat.
FT   CHAIN           1..308
FT                   /note="Peroxisomal targeting signal 2 receptor"
FT                   /id="PRO_0000051119"
FT   REPEAT          57..88
FT                   /note="WD 1"
FT   REPEAT          101..132
FT                   /note="WD 2"
FT   REPEAT          145..176
FT                   /note="WD 3"
FT   REPEAT          187..218
FT                   /note="WD 4"
FT   REPEAT          231..262
FT                   /note="WD 5"
FT   REPEAT          274..306
FT                   /note="WD 6"
SQ   SEQUENCE   308 AA;  34588 MW;  B0FAC61A366F5D67 CRC64;
     MLSLRTPGFQ GESVQFSPLV ENKIAVAAVT HYGLGGSGRL YIHDVTPKGI QVCQHYDVED
     SLFGVRWSQN CENQVYACCG DGSLRLFDLT MPSKPIHKWK EHKAEIVAID TNTVDRRIVV
     TGSWDGTIKL WLGNLPNSVQ TLNNGSNSRI LTVATHYSSP NLLGYTSSDG LCKFWDFRSS
     DKFMSIEIPN QITCMNWSKS NHRMVYTADN NNLVYCYDIA NLKTPLSVLS GHQLAVRSIK
     SSNSAHDLLA TASYDMTSRI FDPEQHSCIR KVDLHSEFVR DVDWSDFGDG SWIASVGWDE
     SLYIWNAF