PEX7_YEAST
ID PEX7_YEAST Reviewed; 375 AA.
AC P39108; D6VSC5;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Peroxisomal targeting signal 2 receptor;
DE Short=PTS2 receptor;
DE AltName: Full=Peroxin-7;
DE AltName: Full=Peroxisome import protein PAS7;
GN Name=PEX7; Synonyms=PAS7, PEB1; OrderedLocusNames=YDR142C;
GN ORFNames=YD2943.01C, YD9302.18C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7957058; DOI=10.1002/j.1460-2075.1994.tb06818.x;
RA Marzioch M., Erdmann R., Veenhuis M., Kunau W.-H.;
RT "PAS7 encodes a novel yeast member of the WD-40 protein family essential
RT for import of 3-oxoacyl-CoA thiolase, a PTS2-containing protein, into
RT peroxisomes.";
RL EMBO J. 13:4908-4918(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / GRF88;
RX PubMed=7535304; DOI=10.1083/jcb.129.1.65;
RA Zhang J.W., Lazarow P.B.;
RT "PEB1 (PAS7) in Saccharomyces cerevisiae encodes a hydrophilic, intra-
RT peroxisomal protein that is a member of the WD repeat family and is
RT essential for the import of thiolase into peroxisomes.";
RL J. Cell Biol. 129:65-80(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=14690591; DOI=10.1016/s1097-2765(03)00476-3;
RA Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M.,
RA Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E.,
RA Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.;
RT "Assigning function to yeast proteins by integration of technologies.";
RL Mol. Cell 12:1353-1365(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Binds to the N-terminal PTS2-type peroxisomal targeting
CC signal and plays an essential role in peroxisomal protein import
CC essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing
CC protein) into peroxisomes. May direct thiolase to peroxisomes by
CC shuttling between the cytosol and peroxisomal membranes.
CC -!- SUBUNIT: Interacts with PEX5.
CC -!- INTERACTION:
CC P39108; P38855: PEX18; NbExp=6; IntAct=EBI-13183, EBI-24803;
CC P39108; P50091: PEX21; NbExp=13; IntAct=EBI-13183, EBI-23549;
CC P39108; P27796: POT1; NbExp=5; IntAct=EBI-13183, EBI-19236;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Peroxisome.
CC -!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the WD repeat peroxin-7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X81424; CAA57183.1; -; Genomic_DNA.
DR EMBL; X83704; CAA58677.1; -; Genomic_DNA.
DR EMBL; Z54139; CAA90811.1; -; Genomic_DNA.
DR EMBL; Z48179; CAA88224.1; -; Genomic_DNA.
DR EMBL; AY557700; AAS56026.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11985.1; -; Genomic_DNA.
DR PIR; S50228; S50228.
DR RefSeq; NP_010426.1; NM_001180449.1.
DR PDB; 3W15; X-ray; 1.80 A; A=1-375.
DR PDBsum; 3W15; -.
DR AlphaFoldDB; P39108; -.
DR SMR; P39108; -.
DR BioGRID; 32196; 79.
DR ComplexPortal; CPX-1905; Peroxisomal PEX7-PEX18 receptor complex.
DR ComplexPortal; CPX-1906; Peroxisomal PEX7-PEX21 receptor complex.
DR DIP; DIP-1501N; -.
DR IntAct; P39108; 56.
DR MINT; P39108; -.
DR STRING; 4932.YDR142C; -.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR iPTMnet; P39108; -.
DR MaxQB; P39108; -.
DR PaxDb; P39108; -.
DR PRIDE; P39108; -.
DR EnsemblFungi; YDR142C_mRNA; YDR142C; YDR142C.
DR GeneID; 851720; -.
DR KEGG; sce:YDR142C; -.
DR SGD; S000002549; PEX7.
DR VEuPathDB; FungiDB:YDR142C; -.
DR eggNOG; KOG0277; Eukaryota.
DR HOGENOM; CLU_046581_1_0_1; -.
DR InParanoid; P39108; -.
DR OMA; EKWNYHT; -.
DR BioCyc; YEAST:G3O-29739-MON; -.
DR Reactome; R-SCE-9033241; Peroxisomal protein import.
DR PRO; PR:P39108; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P39108; protein.
DR GO; GO:0062137; C:cargo receptor complex; IPI:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal.
DR GO; GO:0005829; C:cytosol; IDA:SGD.
DR GO; GO:0005782; C:peroxisomal matrix; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:ComplexPortal.
DR GO; GO:0005777; C:peroxisome; IDA:SGD.
DR GO; GO:0005053; F:peroxisome matrix targeting signal-2 binding; IDA:SGD.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IPI:SGD.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR044536; PEX7.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46027; PTHR46027; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Peroxisome; Protein transport; Reference proteome;
KW Repeat; Transport; WD repeat.
FT CHAIN 1..375
FT /note="Peroxisomal targeting signal 2 receptor"
FT /id="PRO_0000051120"
FT REPEAT 58..89
FT /note="WD 1"
FT REPEAT 102..133
FT /note="WD 2"
FT REPEAT 172..203
FT /note="WD 3"
FT REPEAT 218..249
FT /note="WD 4"
FT REPEAT 281..312
FT /note="WD 5"
FT REPEAT 340..372
FT /note="WD 6"
FT STRAND 2..5
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 9..16
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 23..30
FT /evidence="ECO:0007829|PDB:3W15"
FT HELIX 31..33
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 38..45
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 51..61
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 63..68
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 75..80
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 97..101
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 107..112
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 114..118
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 120..124
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 129..132
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 140..143
FT /evidence="ECO:0007829|PDB:3W15"
FT HELIX 148..153
FT /evidence="ECO:0007829|PDB:3W15"
FT HELIX 158..160
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 177..182
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 189..194
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 197..203
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 210..216
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 223..228
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 235..240
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 245..249
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 274..278
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 281..284
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 286..291
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 298..303
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 308..312
FT /evidence="ECO:0007829|PDB:3W15"
FT TURN 326..328
FT /evidence="ECO:0007829|PDB:3W15"
FT TURN 330..333
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 334..338
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 345..350
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 352..355
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 358..363
FT /evidence="ECO:0007829|PDB:3W15"
FT STRAND 366..372
FT /evidence="ECO:0007829|PDB:3W15"
SQ SEQUENCE 375 AA; 42323 MW; 7D53A42A8ACF23F9 CRC64;
MLRYHMQGFS GYGVQYSPFF DNRLAVAAGS NFGLVGNGKL FILEIDRSGR IVEVNSFLTQ
DCLFDLAWNE SHENQVLVAQ GDGTLRLFDT TFKEFPIAIF KEHEREVFSC NWNLVNRQNF
LSSSWDGSIK IWSPLRKQSL MTLTPRPLEI TKMVDPLNAI ILKKKSFTGI SKNRNCVYQA
QFSPHDQNLV LSCSGNSYAS LFDIRLPSGK NQNNFLVHSG LEALTCDFNK YRPYVVATGG
VDNAIRIWDI RMLNKNESAT IKRTVPGQLH NSSCINEIPN AHGLAIRKVT WSPHHSNILM
SASYDMTCRI WRDLSNDGAK ETYKTNSTDA TKGSIFNFTQ HSEFVFGADW SLWGKPGYVA
STAWDGNLFV WNGLG