ID   PEX8_PICAN              Reviewed;         650 AA.
AC   Q00925;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Peroxisomal biogenesis factor 8;
DE   AltName: Full=Peroxin-8;
DE   AltName: Full=Peroxisomal protein PER1;
GN   Name=PEX8; Synonyms=PER1;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RX   PubMed=7962056; DOI=10.1083/jcb.127.3.737;
RA   Waterham H.R., Titorenko V.I., Haima P., Cregg J.M., Harder W.,
RA   Veenhuis M.;
RT   "The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis
RT   and encodes a peroxisomal matrix protein with both carboxy- and amino-
RT   terminal targeting signals.";
RL   J. Cell Biol. 127:737-749(1994).
CC   -!- FUNCTION: Essential for peroxisome biogenesis. May play a role in
CC       triggering the protein import competence of individual peroxisomes. It
CC       may interact with PEX10.
CC   -!- SUBCELLULAR LOCATION: Peroxisome matrix.
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DR   EMBL; Z30206; CAA82928.1; -; Genomic_DNA.
DR   PIR; A54976; A54976.
DR   AlphaFoldDB; Q00925; -.
DR   GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Peroxisome; Peroxisome biogenesis.
FT   CHAIN           1..650
FT                   /note="Peroxisomal biogenesis factor 8"
FT                   /id="PRO_0000022041"
FT   MOTIF           648..650
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   650 AA;  74122 MW;  A9AC534204F50C7D CRC64;
     MQPWYHKLGR QGRQLAEQWQ TDAEPWGVAT PTPLDYLFDE LTAPKPSTTP DKVLSYLAYY
     YPKLKNENNV ELLTLCFLRC PLFFNDAQLV SFSDNYRVIE CFKYIMDKKF QISQPTLPFY
     RFYNALFGAL AKVVADSACA WKVVPVAVGC LLSVDSRNDY DRYPEHFQLI ATVDAKLVDM
     AAHTLERSMD GPLSNDLLCL NVVALSCVQD KLVDSQLLRI LRVRSDILKI LTELTFNSPY
     GLDNGRLLTK SNANTPIVVR HLNRISFLFT KLTSIHPKIV LLADDLDLIL NRIQTFSESV
     LSIPNPSETQ WSTLRVVLFA QVMMFEGIMA RFFQINNHSL NSTVLPTLCR KILTTLFNFN
     FVVDRIGTGG FESYNFVYAS CLSTLTSYDI PTAETLIKCW TSSVAFKKVD NSATERGKLL
     FDLQFIENVV NLVSDSLKFE FIIPIVQDLI GNAQDQAVLE SAHSVMLKYF TSVDTYNEAQ
     LVDYTNNVKH VGAQLIDYLT LSLDQFPARL SLSQVGIIVE TLAKITFPDT AVHECDPELY
     RELLLLVYNR CLVATSEELP NVQAPPKTRH GAFTSLLIRI LPLIPFDEYQ SWLERTLSLA
     FRTVGDERTY LLDLLWDSIL GTNRHYPQKG YVGIQWWYEH VNESQEKAKL