ID   PEX8_PICPA              Reviewed;         713 AA.
AC   Q01962;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Peroxisomal biogenesis factor 8;
DE   AltName: Full=Peroxin-8;
DE   AltName: Full=Peroxisomal protein PER3;
GN   Name=PEX8; Synonyms=PER3;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7738036; DOI=10.1074/jbc.270.18.10940;
RA   Liu H., Tan X., Russell K.A., Veenhuis M., Cregg J.M.;
RT   "PER3, a gene required for peroxisome biogenesis in Pichia pastoris,
RT   encodes a peroxisomal membrane protein involved in protein import.";
RL   J. Biol. Chem. 270:10940-10951(1995).
CC   -!- FUNCTION: Essential component of the machinery required for the import
CC       of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins.
CC   -!- SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000305}.
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DR   EMBL; L40485; AAC41653.1; -; Genomic_DNA.
DR   PIR; A56439; A56439.
DR   AlphaFoldDB; Q01962; -.
DR   GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Peroxisome.
FT   CHAIN           1..713
FT                   /note="Peroxisomal biogenesis factor 8"
FT                   /id="PRO_0000022042"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           711..713
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   713 AA;  81008 MW;  AABB586B3397C971 CRC64;
     MYRLGSQGRS IQSQLQNGDS SSGRPLQLQG TGMREAQRIP QQLDYLLAEI ISPNEDTNVI
     GYLAYYYPKL KNEQNVALLT DFFLRCPTYF SHSNVVSLRN NYPVMEAFNY IMTTKFKVSQ
     PTVPFYRFYA AVLASLLNCE KTDPSHHWKL IPILTGVLLS IKGRDDVELY PDHSRSIKGS
     DTAVAQLLQR CLLRFYQSGD ARSYDLNALV IISMSCALDY VEDDTIKKIL YCFNYTRAII
     DLIYYSPYGL NDSDIPLLSD SSVNSQSFDQ LLNNNPALKH LNRLSFLFER TVKLNDGSIQ
     SNLNDIDISL NKMQSFSEKL SKKISVLDDD SSKGVGQLLR QCLYASIIIH QAILTTFFQL
     DNADYTKYFL PSFSRKILSI LFNLFFIVDR IGTGGFQPYN FVYLTCLQGI IQYDMKTAES
     LVKTFTTGIN YSSLKDSEVA RAKLLFTLNL MEQIVNICSD DLRLELIVPL VEDLVNNKNA
     CVDIHNHVFK SIFESAHSVI LKFFTVVDSS VKNVDYETNV TLVSEKIIPY LTLVIDQFPE
     FLSINQLDIA IETISRTVFP DSPIYSYDKN ISSMFLNVLF NKCLTVDNDE LVELPAIEAV
     VAPKNDEENN TSDAQDGGPK ELQSLNDLKS RRSALISALI SVFPLIPVKD YTKWLSIAFY
     DLIVATPERT ERAFLQERLW DCVVGTNKYD PQKGNLGIMW WYENVNAQST AKL