ID   PEX9_YARLI              Reviewed;         404 AA.
AC   P45817; Q6C3C9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Peroxisomal biogenesis factor 9;
DE   AltName: Full=Peroxin-9;
DE   AltName: Full=Peroxisomal protein PAY2;
GN   Name=PEX9; Synonyms=PAY2; OrderedLocusNames=YALI0F00748g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E 122;
RX   PubMed=7836411; DOI=10.1074/jbc.270.3.1429;
RA   Eitzen G.A., Aitchison J.D., Szilard R.K., Veenhuis M., Nuttley W.M.,
RA   Rachubinski R.A.;
RT   "The Yarrowia lipolytica gene PAY2 encodes a 42-kDa peroxisomal integral
RT   membrane protein essential for matrix protein import and peroxisome
RT   enlargement but not for peroxisome membrane proliferation.";
RL   J. Biol. Chem. 270:1429-1436(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential for the import of peroxisomal matrix proteins.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: By growth on oleic acid.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-10 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CR382132; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U16653; AAA64562.1; -; Genomic_DNA.
DR   EMBL; CR382132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A55444; A55444.
DR   AlphaFoldDB; P45817; -.
DR   PRIDE; P45817; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..404
FT                   /note="Peroxisomal biogenesis factor 9"
FT                   /id="PRO_0000058344"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          180..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        389
FT                   /note="E -> Q (in Ref. 1; AAA64562)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   404 AA;  44914 MW;  6E6AC1527EDCDE45 CRC64;
     MTMSARVRKM ALPSNCDLSD VEMICDNVLG CLEDLDSSRV VSRVTSREDV DESTIGDLIS
     LDCVSLETPL FSFLFLGVTL FLFLSLLQQS LVFLLGVFLR LVQLVGHFLL LLMGEQIGVI
     DKAMSHIPLP EVGQHSQQVQ IQHLVERRFG LDVVTAIVVI GDNELFQVVG HQFRVGIMSD
     GQRSQQSQNS GMNVASSSRG RHQLVPDRPG SQLSSQKLSS LVPLARIAAA EIPCAVQQSL
     SRLFARSVQN RQVQRPHLDP QRQRNIVGVF GVQHGRAVLL CALGGDLIEK RPNQLVRVVK
     VLVDKFPRRL PKRLVHLVHL GRGSLVHCRC DRVCQQRGCC HLWHCGGHFF VGLVSWIVDE
     TAACVVFCLF KVVSETQRIS SLPRYMHREL NTAGVVWGCG GKHM