PF07_PLAF7
ID PF07_PLAF7 Reviewed; 1119 AA.
AC O77374;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Uncharacterized protein PFC0810c {ECO:0000312|EMBL:CAB11130.1};
DE Flags: Precursor;
GN ORFNames=PFC0810c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3] {ECO:0000312|EMBL:CAB11130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [4] {ECO:0000305}
RP SYNTHESIS OF 180-210, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844502; CAB11130.1; -; Genomic_DNA.
DR PIR; T18491; T18491.
DR RefSeq; XP_001351253.1; XM_001351217.1.
DR AlphaFoldDB; O77374; -.
DR STRING; 5833.PFC0810c; -.
DR PRIDE; O77374; -.
DR EnsemblProtists; CAB11130; CAB11130; PF3D7_0318300.
DR GeneID; 814497; -.
DR KEGG; pfa:PF3D7_0318300; -.
DR VEuPathDB; PlasmoDB:PF3D7_0318300; -.
DR HOGENOM; CLU_280678_0_0_1; -.
DR InParanoid; O77374; -.
DR OMA; MFEDTIN; -.
DR PhylomeDB; O77374; -.
DR Proteomes; UP000001450; Chromosome 3.
PE 1: Evidence at protein level;
KW Coiled coil; Merozoite; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1119
FT /note="Uncharacterized protein PFC0810c"
FT /evidence="ECO:0000255"
FT /id="PRO_0000374061"
FT REGION 606..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 170..206
FT /evidence="ECO:0000255"
FT COILED 890..920
FT /evidence="ECO:0000255"
FT COMPBIAS 790..905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 132983 MW; 25B723D603C09FED CRC64;
MNNIYISLYI FFISYIIQLC FNTKYIYCDK KLYVSKNILP SVEKKEFVSN VPHKLEWLVH
NILEVVHFLE DVNNYIVDFK KDILTKLEHI VQDDTELYES YEYNENLLNQ IYLNNEKKLK
RYSEYIEKLK DTKLQMFEDT INNFQRENIY YLNFVYKNLL AKIDLITNLN KKKLDKEKKK
NVIELKEYLE DLKKRMFDMQ KRLNDIIITK STFLKNESEL NMKLFETSAI DYVNNNSNFE
VFSTYIINDF MLNKKRINVL NYDSNLFFKN NFMYFNFLHN YLKEKKDEHV LNVYIYLKDP
LIQEYELNYF NYYVVLDLYI LDVIIKNVDL LIEKKGKKRK NVNHILVCID NYVVKYNVLS
SNIYLDIQQD IKSFFHESNR NVDGSKIQDM LFHFERKNNS IYQNNMFHDK YYKKKIKKDI
KEEKKQNDSL QKYNKNIDPL LFIRKKNIFF DSQKEYYKKF LSSYTYEEIV NILCNKSSRC
NNRIFQLIND VNKNTFILKS HLALKNELKK FFQINQNKLL KNKTGVGLIN STKDDINRIT
NMNLATNTNN AMGNITNDSN IINTNNNNNT SDINNNNTSD INNNNTNNIN NNNTNNINNN
NTNNINNNTN NTNNNSNNNN NNNIFNNEDS LNKCSAYTYP FSNDAEKNYQ ENRNQSFSNS
DHCFKLLNSI QGANKSSDFI NMQNIDDYLN TYYVAYHESF KVVKKEHYYS VISHIFESYL
NIDESSNDDD HPIHKKYPHL KGRNVSINFL GQLPEIMKVY KTFRYCDSLN VLAKSYIPKS
PASVQSLDKG EDNNDNDEKG ESGEDTQVIE KDDSGEDRQM IEKDDSGEDR QMIEKDDSGE
DRQMIEKDDS GEDRQMIEKD DSGEDRQMIE KDDSGEDRQM IEKDKSRDDN KAQNNNSTDN
EEHDEITEQI GFLKNHNQKY MRLFQKHLLE EIKFINFFEF LVQKKLGVIL EKNEFLKLYI
FYGQKNLPSM PYTPLFFTCR TIIKIEVLRD VNTNQIIYSS RSFFLETLIT LKEYKIKNES
AYIVIETTDE SSTIKKRLKM DMLHKISPMS HINAYVISNK GKEIVYHKGN IYQRSASDIK
NVISDIRNDF LNIILPQYHL FDLFDNYVYI IICLKNENC
