PF12P_PLAF7
ID PF12P_PLAF7 Reviewed; 371 AA.
AC C6KSX1;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Surface protein P12p;
DE Flags: Precursor;
GN Name=PFS12P; Synonyms=PF12P; ORFNames=PFF0620c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=16155126; DOI=10.1073/pnas.0502378102;
RA Gerloff D.L., Creasey A., Maslau S., Carter R.;
RT "Structural models for the protein family characterized by gamete surface
RT protein Pfs230 of Plasmodium falciparum.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13598-13603(2005).
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000250}. Cell membrane
CC {ECO:0000250}.
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DR EMBL; AL844505; CAG25367.1; -; Genomic_DNA.
DR RefSeq; XP_966115.1; XM_961022.1.
DR PDB; 7KJ7; X-ray; 2.80 A; A/B=24-341.
DR PDB; 7KJH; X-ray; 2.00 A; C/D=24-341.
DR PDB; 7KJI; X-ray; 3.25 A; B=24-341.
DR PDBsum; 7KJ7; -.
DR PDBsum; 7KJH; -.
DR PDBsum; 7KJI; -.
DR AlphaFoldDB; C6KSX1; -.
DR SMR; C6KSX1; -.
DR STRING; 5833.PFF0620c; -.
DR SwissPalm; C6KSX1; -.
DR EnsemblProtists; CAG25367; CAG25367; PF3D7_0612800.
DR GeneID; 3885776; -.
DR KEGG; pfa:PF3D7_0612800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0612800; -.
DR HOGENOM; CLU_845892_0_0_1; -.
DR InParanoid; C6KSX1; -.
DR OMA; FEKVRIN; -.
DR PhylomeDB; C6KSX1; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.2860; -; 2.
DR InterPro; IPR010884; 6_CYS_dom.
DR InterPro; IPR038160; 6_CYS_dom_sf.
DR Pfam; PF07422; s48_45; 2.
DR SMART; SM00970; s48_45; 2.
DR PROSITE; PS51701; 6_CYS; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; Glycoprotein; Malaria;
KW Membrane; Reference proteome; Repeat; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..371
FT /note="Surface protein P12p"
FT /id="PRO_0000423568"
FT DOMAIN 23..168
FT /note="6-Cys 1"
FT DOMAIN 169..343
FT /note="6-Cys 2"
FT REGION 202..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..62
FT /evidence="ECO:0000250"
FT DISULFID 76..144
FT /evidence="ECO:0000250"
FT DISULFID 93..142
FT /evidence="ECO:0000250"
FT DISULFID 173..245
FT /evidence="ECO:0000250"
FT DISULFID 260..323
FT /evidence="ECO:0000250"
FT DISULFID 271..321
FT /evidence="ECO:0000250"
FT STRAND 25..28
FT /evidence="ECO:0007829|PDB:7KJH"
FT HELIX 32..34
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 58..66
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 68..77
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 87..90
FT /evidence="ECO:0007829|PDB:7KJH"
FT TURN 91..95
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 96..99
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 102..105
FT /evidence="ECO:0007829|PDB:7KJH"
FT HELIX 106..109
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 114..119
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 121..130
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 138..145
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 158..165
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 170..177
FT /evidence="ECO:0007829|PDB:7KJH"
FT HELIX 179..182
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 187..193
FT /evidence="ECO:0007829|PDB:7KJH"
FT HELIX 194..197
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 243..249
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 251..259
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 264..268
FT /evidence="ECO:0007829|PDB:7KJH"
FT TURN 269..272
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 273..277
FT /evidence="ECO:0007829|PDB:7KJH"
FT TURN 278..280
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 281..284
FT /evidence="ECO:0007829|PDB:7KJH"
FT HELIX 285..288
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 294..297
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 301..309
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 319..325
FT /evidence="ECO:0007829|PDB:7KJH"
FT STRAND 327..329
FT /evidence="ECO:0007829|PDB:7KJ7"
FT STRAND 334..340
FT /evidence="ECO:0007829|PDB:7KJH"
SQ SEQUENCE 371 AA; 43460 MW; 8A81197CA8F81BC2 CRC64;
MHIVSFIIFF FALFFPISIC YKINGVCDFS SEGLSLLPEE KLDFSVSRNV DKLSDENNVR
HCVHFSKGFE YLRFICPMRK DNYEGIEIRP VECFEYIHIE GREHKLSEIL KGSLYEKSIN
DNIMTRDVFI PPTIYEDMFF ECTCDNSLTF KNNMIGIRGI MKIHLKKNIL YGCDFDHDEK
LMKNKTAFTN FYDKQKILPL IGNNNNDDDN NDDDNNNDNN NNDNNNNNNN NNNNNNNNNN
NNITCNVTIK KSQVYLGIIC PDGYTLYPND CFKNVIYDNN IIIPLKKIIP HDILYHQDKN
KRITFASFTL NINENPPGFT CYCIKDQTNI NNPLIVNFHF SNQETSYATK NKNLFFYFIF
IFPFLYVILL L
