PF21B_HUMAN
ID PF21B_HUMAN Reviewed; 531 AA.
AC Q96EK2; B0QYW3; B0QYW4; B3KRU4; B7Z4F8; Q5TFL2; Q6ICC0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=PHD finger protein 21B;
GN Name=PHF21B; Synonyms=KIAA1661;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96EK2-3; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-16437793, EBI-11524452;
CC Q96EK2-3; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-16437793, EBI-1504830;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96EK2-1; Sequence=Displayed;
CC Name=2; Synonyms=3;
CC IsoId=Q96EK2-3; Sequence=VSP_017456;
CC Name=3;
CC IsoId=Q96EK2-4; Sequence=VSP_043149, VSP_017456;
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DR EMBL; CR456448; CAG30334.1; -; mRNA.
DR EMBL; AK092243; BAG52506.1; -; mRNA.
DR EMBL; AK297317; BAH12544.1; -; mRNA.
DR EMBL; AL049760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z83838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73366.1; -; Genomic_DNA.
DR EMBL; BC012187; AAH12187.1; -; mRNA.
DR CCDS; CCDS14061.1; -. [Q96EK2-1]
DR CCDS; CCDS46727.1; -. [Q96EK2-3]
DR CCDS; CCDS56234.1; -. [Q96EK2-4]
DR RefSeq; NP_001129334.1; NM_001135862.2. [Q96EK2-3]
DR RefSeq; NP_001229379.1; NM_001242450.1. [Q96EK2-4]
DR RefSeq; NP_001271225.1; NM_001284296.1.
DR RefSeq; NP_612424.1; NM_138415.4. [Q96EK2-1]
DR RefSeq; XP_006724185.1; XM_006724122.1. [Q96EK2-3]
DR AlphaFoldDB; Q96EK2; -.
DR SMR; Q96EK2; -.
DR BioGRID; 125214; 18.
DR CORUM; Q96EK2; -.
DR IntAct; Q96EK2; 16.
DR MINT; Q96EK2; -.
DR STRING; 9606.ENSP00000324403; -.
DR GlyGen; Q96EK2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96EK2; -.
DR PhosphoSitePlus; Q96EK2; -.
DR BioMuta; PHF21B; -.
DR DMDM; 74731574; -.
DR MassIVE; Q96EK2; -.
DR MaxQB; Q96EK2; -.
DR PaxDb; Q96EK2; -.
DR PeptideAtlas; Q96EK2; -.
DR PRIDE; Q96EK2; -.
DR ProteomicsDB; 76413; -. [Q96EK2-1]
DR ProteomicsDB; 76414; -. [Q96EK2-3]
DR ProteomicsDB; 76415; -. [Q96EK2-4]
DR Antibodypedia; 27774; 145 antibodies from 17 providers.
DR DNASU; 112885; -.
DR Ensembl; ENST00000313237.10; ENSP00000324403.5; ENSG00000056487.16. [Q96EK2-1]
DR Ensembl; ENST00000396103.7; ENSP00000379410.4; ENSG00000056487.16. [Q96EK2-4]
DR Ensembl; ENST00000629843.2; ENSP00000487086.1; ENSG00000056487.16. [Q96EK2-3]
DR GeneID; 112885; -.
DR KEGG; hsa:112885; -.
DR MANE-Select; ENST00000313237.10; ENSP00000324403.5; NM_138415.5; NP_612424.1.
DR UCSC; uc003bfn.4; human. [Q96EK2-1]
DR CTD; 112885; -.
DR DisGeNET; 112885; -.
DR GeneCards; PHF21B; -.
DR HGNC; HGNC:25161; PHF21B.
DR HPA; ENSG00000056487; Tissue enhanced (cervix, pituitary gland).
DR MIM; 616727; gene.
DR neXtProt; NX_Q96EK2; -.
DR OpenTargets; ENSG00000056487; -.
DR PharmGKB; PA134872136; -.
DR VEuPathDB; HostDB:ENSG00000056487; -.
DR eggNOG; KOG0383; Eukaryota.
DR GeneTree; ENSGT00940000161105; -.
DR HOGENOM; CLU_020260_1_0_1; -.
DR InParanoid; Q96EK2; -.
DR OMA; QSWIKST; -.
DR PhylomeDB; Q96EK2; -.
DR TreeFam; TF331518; -.
DR PathwayCommons; Q96EK2; -.
DR SignaLink; Q96EK2; -.
DR BioGRID-ORCS; 112885; 9 hits in 1069 CRISPR screens.
DR ChiTaRS; PHF21B; human.
DR GenomeRNAi; 112885; -.
DR Pharos; Q96EK2; Tbio.
DR PRO; PR:Q96EK2; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q96EK2; protein.
DR Bgee; ENSG00000056487; Expressed in ganglionic eminence and 92 other tissues.
DR ExpressionAtlas; Q96EK2; baseline and differential.
DR Genevisible; Q96EK2; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..531
FT /note="PHD finger protein 21B"
FT /id="PRO_0000226769"
FT ZN_FING 352..399
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 79..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..465
FT /evidence="ECO:0000255"
FT COMPBIAS 238..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..17
FT /note="MELQSRPEALAVELARH -> MRRQP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043149"
FT VAR_SEQ 189..230
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15461802"
FT /id="VSP_017456"
FT VARIANT 127
FT /note="G -> S (in dbSNP:rs8135982)"
FT /id="VAR_051601"
SQ SEQUENCE 531 AA; 57455 MW; 5EFBAAEC1D952941 CRC64;
MELQSRPEAL AVELARHQNG DLKKQLHERQ PRIAALSDKQ ALGTITAVPV TGPQVSSLQR
LAGQGAAVLP QVRPKTLIPD SLPVAPGRDR PPKQPPTFQK ATVVSVKNPS PALPTANNTV
SHVPAPGSQP QALAEPAALA SPLSSAGVAY AIISTSPSNA AAMAPSTAVS VVSDSIKVQP
LLISADNKPP PRLLSSPHPA THHCPLHPSS LPLTPPSPSL SPSPLHGIFQ VIIIQPQVQT
QPESTAESRP PTEEPSQGAQ ATKKKKEDRP PTQENPEKIA FMVALGLVTT EHLEEIQSKR
QERKRRSTAN PAYSGLLETE RKRLASNYLN NPLFLTARAN EDPCWKNEIT HDEHCAACKR
GANLQPCGTC PGAYHLSCLE PPLKTAPKGV WVCPRCQQKA LKKDEGVPWT GMLAIVHSYV
THKTVKEEEK QKLLQRGSEL QNEHQQLEER DRRLASAVQK CLELKTSLLA RQRGTQSSLD
RLRALLRLIQ GEQLLQVTMT TTSPAPLLAG PWTKPSVAAT HPTVQHPQGH N
