PF21B_MOUSE
ID PF21B_MOUSE Reviewed; 487 AA.
AC Q8C966;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=PHD finger protein 21B;
GN Name=Phf21b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AK042863; BAC31386.1; -; mRNA.
DR CCDS; CCDS37169.2; -.
DR RefSeq; NP_001074635.2; NM_001081166.2.
DR AlphaFoldDB; Q8C966; -.
DR SMR; Q8C966; -.
DR BioGRID; 234835; 4.
DR STRING; 10090.ENSMUSP00000125355; -.
DR PhosphoSitePlus; Q8C966; -.
DR MaxQB; Q8C966; -.
DR PaxDb; Q8C966; -.
DR PRIDE; Q8C966; -.
DR ProteomicsDB; 289350; -.
DR Antibodypedia; 27774; 145 antibodies from 17 providers.
DR Ensembl; ENSMUST00000159939; ENSMUSP00000125355; ENSMUSG00000016624.
DR GeneID; 271305; -.
DR KEGG; mmu:271305; -.
DR UCSC; uc007xco.2; mouse.
DR CTD; 112885; -.
DR MGI; MGI:2443812; Phf21b.
DR VEuPathDB; HostDB:ENSMUSG00000016624; -.
DR eggNOG; KOG0383; Eukaryota.
DR GeneTree; ENSGT00940000161105; -.
DR HOGENOM; CLU_020260_0_0_1; -.
DR InParanoid; Q8C966; -.
DR OMA; QSWIKST; -.
DR OrthoDB; 1185408at2759; -.
DR PhylomeDB; Q8C966; -.
DR TreeFam; TF331518; -.
DR BioGRID-ORCS; 271305; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Phf21b; mouse.
DR PRO; PR:Q8C966; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8C966; protein.
DR Bgee; ENSMUSG00000016624; Expressed in cortical plate and 80 other tissues.
DR ExpressionAtlas; Q8C966; baseline and differential.
DR Genevisible; Q8C966; MM.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..487
FT /note="PHD finger protein 21B"
FT /id="PRO_0000226770"
FT ZN_FING 307..354
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 196..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 380..420
FT /evidence="ECO:0000255"
FT COMPBIAS 196..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 53002 MW; 14852A68FBA6FC4D CRC64;
MELQSRSEAL AVELARHQNG DLKKQLHERQ PRIAALSDKQ ALGSTTAVPV TGPQVSSLQR
LAGQGAAVLP QVRPKTLIPD SLPVTPGRDR PPKQPPTFQK ATVVSIKNPS PALPTANNTV
NHVPTPSSQT QALTEPTAIT SPLSSAGVAY AIISTSPSNA ATITPSTTVP VASDGIKVQP
LLISADKKVI IIQPQVKTQP ESSAEPEPPT EEPSQGAQAT KEDQPPSKEN PEKIAFMVAL
GLVTTEHLEE IQSKRQERKR RSTANPAYSG FLETERKRLA SSYLHNPLFL TARANEDPCW
KGEITHDEFC AACKRGASLQ PCGTCSGAYH LSCLDPPLKT PPKGLWVCPK CQRKALKKDE
GVPWTGMLAI VHSYVTHKTV KEEEKQKLLQ RGSELQSEHQ QLEERDRQLA SAVKKCLELK
TSLLARQRGT QSSLDRIRAL LRLIQGEQML QVAMATTSPT PLLAGPWTKP STTTTMRTTL
QHPQNHN
