PF23A_DANRE
ID PF23A_DANRE Reviewed; 296 AA.
AC Q5BJ10;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=PHD finger protein 23A {ECO:0000305};
GN Name=phf23a {ECO:0000305}; ORFNames=si:ch211-137i24.4, zgc:112942;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a negative regulator of autophagy.
CC {ECO:0000250|UniProtKB:Q9BUL5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUL5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9BUL5}.
CC -!- DOMAIN: The PHD-type zinc-finger domain is required for negative
CC regulation of autophagy. {ECO:0000250|UniProtKB:Q9BUL5}.
CC -!- SIMILARITY: Belongs to the PHF23 family. {ECO:0000305}.
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DR EMBL; BX119902; CAM13207.1; -; Genomic_DNA.
DR EMBL; BC091667; AAH91667.1; -; mRNA.
DR RefSeq; NP_001013517.1; NM_001013499.1.
DR AlphaFoldDB; Q5BJ10; -.
DR STRING; 7955.ENSDARP00000105631; -.
DR PaxDb; Q5BJ10; -.
DR PRIDE; Q5BJ10; -.
DR Ensembl; ENSDART00000042481; ENSDARP00000042480; ENSDARG00000030887.
DR GeneID; 541372; -.
DR KEGG; dre:541372; -.
DR CTD; 541372; -.
DR ZFIN; ZDB-GENE-050320-67; phf23a.
DR eggNOG; KOG1844; Eukaryota.
DR GeneTree; ENSGT00530000063882; -.
DR HOGENOM; CLU_047981_0_0_1; -.
DR InParanoid; Q5BJ10; -.
DR OMA; KEERAWT; -.
DR OrthoDB; 982722at2759; -.
DR PhylomeDB; Q5BJ10; -.
DR TreeFam; TF331373; -.
DR PRO; PR:Q5BJ10; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000030887; Expressed in blastula and 22 other tissues.
DR ExpressionAtlas; Q5BJ10; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:GO_Central.
DR GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..296
FT /note="PHD finger protein 23A"
FT /id="PRO_0000302833"
FT ZN_FING 239..287
FT /note="PHD-type"
FT REGION 50..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 33431 MW; EB35CBF94DA696EC CRC64;
MLGIMDHHQD TVRKCKSEAL PPERRKRTVE DFNKFCSFVL TYAGYIPPQK EESSWSPSSS
PCTHDLSELS GEGSVKDSWT DSHSDLNNIH NLVYKAETDS SSSREFSHLP SDNSLDKMTL
KDSLNHVHSK AERKKVKKLD RLSLGGPRKS ISEARAHKQS KAALKKIKTS IKAERHFTSS
SPLNEGFEKE ELTEQAIHMH EAGLKLESNQ ETDLSSCETD TLVTDEDIMV ESGDDSWDLI
TCYCGKPFAG RPMIECEECS IWVHLSCAKI KKSNVPDIFY CYRCLDSRGS TVKRDH
