ID   PF23B_DANRE             Reviewed;         315 AA.
AC   Q7SXB5; Q503K5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=PHD finger protein 23B {ECO:0000305};
GN   Name=phf23b {ECO:0000305}; ORFNames=zgc:110484, zgc:66469;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of autophagy.
CC       {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUL5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- DOMAIN: The PHD-type zinc-finger domain is required for negative
CC       regulation of autophagy. {ECO:0000250|UniProtKB:Q9BUL5}.
CC   -!- SIMILARITY: Belongs to the PHF23 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95292.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC055673; AAH55673.1; -; mRNA.
DR   EMBL; BC095292; AAH95292.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_956138.1; NM_199844.1.
DR   AlphaFoldDB; Q7SXB5; -.
DR   SMR; Q7SXB5; -.
DR   STRING; 7955.ENSDARP00000107356; -.
DR   PaxDb; Q7SXB5; -.
DR   Ensembl; ENSDART00000159826; ENSDARP00000136826; ENSDARG00000036305.
DR   Ensembl; ENSDART00000164050; ENSDARP00000133597; ENSDARG00000036305.
DR   GeneID; 100004597; -.
DR   KEGG; dre:100004597; -.
DR   CTD; 100004597; -.
DR   ZFIN; ZDB-GENE-030131-5895; phf23b.
DR   eggNOG; KOG1844; Eukaryota.
DR   GeneTree; ENSGT00530000063882; -.
DR   InParanoid; Q7SXB5; -.
DR   OrthoDB; 982722at2759; -.
DR   PhylomeDB; Q7SXB5; -.
DR   TreeFam; TF331373; -.
DR   PRO; PR:Q7SXB5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036305; Expressed in cleaving embryo and 26 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISS:GO_Central.
DR   GO; GO:1901097; P:negative regulation of autophagosome maturation; ISS:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..315
FT                   /note="PHD finger protein 23B"
FT                   /id="PRO_0000302834"
FT   ZN_FING         258..306
FT                   /note="PHD-type"
FT   REGION          51..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        280
FT                   /note="V -> I (in Ref. 1; AAH95292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  34989 MW;  F83A4B9DBEFD64F3 CRC64;
     MLEIMSEHQD SLLKCKAETL PSERRKRTVE DFNKFCSFVL AYANYIPSQK EEGPWSPASS
     SSPNGSGASG EGSVLGGASS NMSPSWNHGT SDLHTIHTFV HKARANKSSK SMRRLSPDGA
     LEDNMCLKDS FYESQAASKA ERKKDKKLKR LSLGSGAGDS SSSGGEKRAR IKHSKNSKQS
     KAYKKLKSSA HSESDSENGL GHREERSEHR LQVQVKEEKN EEDEEEAIRE ADMSSSEGET
     WIADEDIMVE SGDDSWDLIT CYCGKPFAGR PMIECSQCNV WVHLSCAKIK KSNVPDIFNC
     HKCRDSRRSS HKKDS