PF2R_BOVIN
ID PF2R_BOVIN Reviewed; 362 AA.
AC P37289;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=Prostaglandin F2-alpha receptor;
DE Short=PGF receptor;
DE Short=PGF2-alpha receptor;
DE AltName: Full=Prostanoid FP receptor;
GN Name=PTGFR;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Corpus luteum;
RX PubMed=7508922; DOI=10.1016/s0021-9258(17)41942-9;
RA Sakamoto K., Ezashi T., Miwa K., Okuda-Ashitaka E., Houtani T.,
RA Sugimoto T., Ito S., Hayaishi O.;
RT "Molecular cloning and expression of a cDNA of the bovine prostaglandin F2
RT alpha receptor.";
RL J. Biol. Chem. 269:3881-3886(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=9197544; DOI=10.1016/s0378-1119(97)00012-7;
RA Ezashi T., Sakamoto K., Miwa K., Okuda-Ashitaka E., Ito S., Hayaishi O.;
RT "Genomic organization and characterization of the gene encoding bovine
RT prostaglandin F2alpha receptor.";
RL Gene 190:271-278(1997).
CC -!- FUNCTION: Receptor for prostaglandin F2-alpha (PGF2-alpha). The
CC activity of this receptor is mediated by G proteins which activate a
CC phosphatidylinositol-calcium second messenger system. Initiates
CC luteolysis in the corpus luteum (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; D17395; BAA04218.1; -; mRNA.
DR EMBL; D89039; BAA20871.1; -; Genomic_DNA.
DR PIR; A53058; A53058.
DR RefSeq; NP_851368.1; NM_181025.3.
DR RefSeq; XP_005204428.1; XM_005204371.3.
DR AlphaFoldDB; P37289; -.
DR SMR; P37289; -.
DR STRING; 9913.ENSBTAP00000041321; -.
DR BindingDB; P37289; -.
DR ChEMBL; CHEMBL4820; -.
DR DrugCentral; P37289; -.
DR PaxDb; P37289; -.
DR GeneID; 282020; -.
DR KEGG; bta:282020; -.
DR CTD; 5737; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P37289; -.
DR OrthoDB; 972015at2759; -.
DR TreeFam; TF324982; -.
DR PRO; PR:P37289; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004958; F:prostaglandin F receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000141; PglndnF_rcpt.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001244; Prostglndn_DP_rcpt.
DR PANTHER; PTHR11866; PTHR11866; 1.
DR PANTHER; PTHR11866:SF4; PTHR11866:SF4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00428; PROSTAGLNDNR.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00855; PRSTNOIDFPR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..362
FT /note="Prostaglandin F2-alpha receptor"
FT /id="PRO_0000070069"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 108..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 340
FT /note="D -> N (in Ref. 2; BAA20871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 362 AA; 41032 MW; 041AC4D696C3CC57 CRC64;
MSTNSSIQPV SPESELLSNT TCQLEEDLSI SFSIIFMTVG ILSNSLAIAI LMKAYQRFRQ
KYKSSFLLLA SALVITDFFG HLINGTIAVF VYASDKDWIY FDKSNILCSI FGICMVFSGL
CPLFLGSLMA IERCIGVTKP IFHSTKITTK HVKMMLSGVC FFAVFVALLP ILGHRDYKIQ
ASRTWCFYKT DEIKDWEDRF YLLLFAFLGL LALGISFVCN AITGISLLKV KFRSQQHRQG
RSHHFEMVIQ LLGIMCVSCI CWSPFLVTMA SIGMNIQDFK DSCERTLFTL RMATWNQILD
PWVYILLRKA VLRNLYVCTR RCCGVHVISL HVWELSSIKD SLKVAAISDL PVTEKVTQQT
ST
