PF36P_PLABA
ID PF36P_PLABA Reviewed; 441 AA.
AC Q4Z4D2;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Sporozoite surface protein P36p;
DE AltName: Full=Sporozoite surface protein P52;
DE AltName: Full=Sporozoite surface protein Pbs36p;
DE Flags: Precursor;
GN Name=P52; Synonyms=PBS36P; ORFNames=PB000891.00.0;
OS Plasmodium berghei (strain Anka).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANKA;
RX PubMed=15637271; DOI=10.1126/science.1103717;
RA Hall N., Karras M., Raine J.D., Carlton J.M., Kooij T.W.A., Berriman M.,
RA Florens L., Janssen C.S., Pain A., Christophides G.K., James K.,
RA Rutherford K., Harris B., Harris D., Churcher C.M., Quail M.A., Ormond D.,
RA Doggett J., Trueman H.E., Mendoza J., Bidwell S.L., Rajandream M.A.,
RA Carucci D.J., Yates J.R. III, Kafatos F.C., Janse C.J., Barrell B.G.,
RA Turner C.M.R., Waters A.P., Sinden R.S.;
RT "A comprehensive survey of the Plasmodium life cycle by genomic,
RT transcriptomic, and proteomic analyses.";
RL Science 307:82-86(2005).
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND GPI-ANCHOR.
RC STRAIN=ANKA;
RX PubMed=16313615; DOI=10.1111/j.1365-2958.2005.04801.x;
RA Ishino T., Chinzei Y., Yuda M.;
RT "Two proteins with 6-cys motifs are required for malarial parasites to
RT commit to infection of the hepatocyte.";
RL Mol. Microbiol. 58:1264-1275(2005).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ANKA;
RX PubMed=16103357; DOI=10.1073/pnas.0500925102;
RA van Dijk M.R., Douradinha B., Franke-Fayard B., Heussler V.,
RA van Dooren M.W., van Schaijk B., van Gemert G.J., Sauerwein R.W.,
RA Mota M.M., Waters A.P., Janse C.J.;
RT "Genetically attenuated, P36p-deficient malarial sporozoites induce
RT protective immunity and apoptosis of infected liver cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12194-12199(2005).
RN [4]
RP FUNCTION.
RC STRAIN=ANKA;
RX PubMed=17604034; DOI=10.1016/j.ijpara.2007.05.005;
RA Douradinha B., van Dijk M.R., Ataide R., van Gemert G.J., Thompson J.,
RA Franetich J.F., Mazier D., Luty A.J., Sauerwein R., Janse C.J.,
RA Waters A.P., Mota M.M.;
RT "Genetically attenuated P36p-deficient Plasmodium berghei sporozoites
RT confer long-lasting and partial cross-species protection.";
RL Int. J. Parasitol. 37:1511-1519(2007).
RN [5]
RP DEVELOPMENTAL STAGE.
RC STRAIN=ANKA;
RX PubMed=20386715; DOI=10.1371/journal.ppat.1000853;
RA van Dijk M.R., van Schaijk B.C., Khan S.M., van Dooren M.W., Ramesar J.,
RA Kaczanowski S., van Gemert G.J., Kroeze H., Stunnenberg H.G., Eling W.M.,
RA Sauerwein R.W., Waters A.P., Janse C.J.;
RT "Three members of the 6-cys protein family of Plasmodium play a role in
RT gamete fertility.";
RL PLoS Pathog. 6:E1000853-E1000853(2010).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ANKA;
RX PubMed=23227206; DOI=10.1371/journal.pone.0050772;
RA Ploemen I.H., Croes H.J., van Gemert G.J., Wijers-Rouw M., Hermsen C.C.,
RA Sauerwein R.W.;
RT "Plasmodium berghei Deltap52&p36 parasites develop independent of a
RT parasitophorous vacuole membrane in Huh-7 liver cells.";
RL PLoS ONE 7:E50772-E50772(2012).
CC -!- FUNCTION: Involved in sporozoite infection of hepatocytes and
CC replication therein. {ECO:0000269|PubMed:16103357,
CC ECO:0000269|PubMed:16313615, ECO:0000269|PubMed:17604034,
CC ECO:0000269|PubMed:23227206}.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:16313615}. Cell
CC membrane {ECO:0000305|PubMed:16313615}; Lipid-anchor, GPI-anchor
CC {ECO:0000305|PubMed:16313615}. Note=Present on the surface of
CC sporozoites.
CC -!- DEVELOPMENTAL STAGE: Specifically expressed in liver-infective
CC sporozoites. Not expressed in blood stages.
CC {ECO:0000269|PubMed:20386715}.
CC -!- DISRUPTION PHENOTYPE: Attenuated parasites that cannot commit to
CC infection, even when they encounter with hepatocytes, resulting in
CC continuous traversal of hepatocytes. Cells lacking both PBS36 and
CC P52/PBS36P are severely affected in their capability to develop into
CC liver stage parasites and abort development soon after invasion;
CC possibly due to the absence of a parasitophorous vacuole membrane
CC (PVM). {ECO:0000269|PubMed:16103357, ECO:0000269|PubMed:16313615,
CC ECO:0000269|PubMed:23227206}.
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DR EMBL; CAAI01000664; CAH94851.1; -; Genomic_DNA.
DR RefSeq; XP_680035.1; XM_674943.1.
DR AlphaFoldDB; Q4Z4D2; -.
DR SMR; Q4Z4D2; -.
DR STRING; 5821.PBANKA_100220; -.
DR eggNOG; ENOG502TN9V; Eukaryota.
DR InParanoid; Q4Z4D2; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.2860; -; 1.
DR InterPro; IPR010884; 6_CYS_dom.
DR InterPro; IPR038160; 6_CYS_dom_sf.
DR Pfam; PF07422; s48_45; 1.
DR SMART; SM00970; s48_45; 1.
DR PROSITE; PS51701; 6_CYS; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Malaria; Membrane; Repeat; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..418
FT /note="Sporozoite surface protein P36p"
FT /id="PRO_0000423575"
FT PROPEP 419..441
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000423576"
FT DOMAIN 23..156
FT /note="6-Cys 1"
FT DOMAIN 159..298
FT /note="6-Cys 2"
FT REGION 328..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 418
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 305
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 352
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 37..49
FT /evidence="ECO:0000250"
FT DISULFID 63..137
FT /evidence="ECO:0000250"
FT DISULFID 80..135
FT /evidence="ECO:0000250"
FT DISULFID 163..187
FT /evidence="ECO:0000250"
FT DISULFID 201..280
FT /evidence="ECO:0000250"
FT DISULFID 221..278
FT /evidence="ECO:0000250"
SQ SEQUENCE 441 AA; 51507 MW; 9419227C13C92574 CRC64;
MKRRRIFMYY CFCFLLKYVA FSNVTNPNTT LGHFEICKIN IYSGDAEECV LENEFGKMFL
FICDIDYNEM SKNIVLPSEC AKKTYIDHVN PNGTSPEVNT YDIFPDLIGA NESKFRDKFY
FYGTPYSSKD IDFICLCFSE VKPDIKHIIK MSFKKMTKKI KGCDFGDNVP TKKDLTNGKA
LYENSSCHIY AYPGDVIGIN CYKKDINNIY NNNLELSPNN CFHNVYYEND ILLSSKNLIP
NSRVIPDPSN DVKLSKMHSY MSYIILPDEI NENVKISCSC KRNEYVGTMF LYVNTSKNIL
TYTGNNSIIS NHANKKYYEH MKIYKGNKMD PSDEDESNEN AHNGNRANKD ANYSEKMVDN
RRQKNNSLNH TNYHGNYNEN DNEINISTHD KYYEDHHLGS NRPLRKKRTF WQNLFGTSSS
YYEVFNYFSI AFILIIHMLL W