PF36_PLAF7
ID PF36_PLAF7 Reviewed; 379 AA.
AC Q8I1Y5;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Sporozoite surface protein P36;
DE Flags: Precursor;
GN Name=PF36; ORFNames=PFD0210c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19625622; DOI=10.1073/pnas.0906387106;
RA VanBuskirk K.M., O'Neill M.T., De La Vega P., Maier A.G., Krzych U.,
RA Williams J., Dowler M.G., Sacci J.B. Jr., Kangwanrangsan N., Tsuboi T.,
RA Kneteman N.M., Heppner D.G. Jr., Murdock B.A., Mikolajczak S.A., Aly A.S.,
RA Cowman A.F., Kappe S.H.;
RT "Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates
RT by design.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:13004-13009(2009).
CC -!- FUNCTION: Involved in sporozoite infection of hepatocytes and
CC replication therein. {ECO:0000269|PubMed:19625622}.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000250}. Cell membrane
CC {ECO:0000250}. Note=Present on the surface of sporozoite.
CC {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Attenuated parasites that cannot commit to
CC infection, even when they encounter with hepatocytes, resulting in
CC continuous traversal of hepatocytes. {ECO:0000269|PubMed:19625622}.
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DR EMBL; AL844503; CAD49136.2; -; Genomic_DNA.
DR RefSeq; XP_001351356.2; XM_001351320.2.
DR AlphaFoldDB; Q8I1Y5; -.
DR SMR; Q8I1Y5; -.
DR BioGRID; 1207788; 7.
DR IntAct; Q8I1Y5; 6.
DR STRING; 5833.PFD0210c; -.
DR EnsemblProtists; CAD49136; CAD49136; PF3D7_0404400.
DR GeneID; 812450; -.
DR KEGG; pfa:PF3D7_0404400; -.
DR VEuPathDB; PlasmoDB:PF3D7_0404400; -.
DR HOGENOM; CLU_786380_0_0_1; -.
DR InParanoid; Q8I1Y5; -.
DR OMA; VGINCIN; -.
DR PhylomeDB; Q8I1Y5; -.
DR Proteomes; UP000001450; Chromosome 4.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.2860; -; 2.
DR InterPro; IPR010884; 6_CYS_dom.
DR InterPro; IPR038160; 6_CYS_dom_sf.
DR Pfam; PF07422; s48_45; 1.
DR SMART; SM00970; s48_45; 1.
DR PROSITE; PS51701; 6_CYS; 2.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Malaria; Membrane;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..379
FT /note="Sporozoite surface protein P36"
FT /id="PRO_0000423570"
FT DOMAIN 69..206
FT /note="6-Cys 1"
FT DOMAIN 215..379
FT /note="6-Cys 2"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..101
FT /evidence="ECO:0000250"
FT DISULFID 115..186
FT /evidence="ECO:0000250"
FT DISULFID 129..184
FT /evidence="ECO:0000250"
FT DISULFID 219..243
FT /evidence="ECO:0000250"
FT DISULFID 257..360
FT /evidence="ECO:0000250"
FT DISULFID 295..358
FT /evidence="ECO:0000250"
SQ SEQUENCE 379 AA; 44568 MW; EE466749E5CD2B52 CRC64;
MAYNIWEEYI MANFHNVYPV VTNLFLFIAL SYSFCIFVFF SFFFVKMRKV IYFFLIICLH
SNVGWHPFFV FFCGVSGLYV KELQVGNYYI CNLKDYANET CTVNYDYNKM IKLLCPINKS
YEEYDDRYCF KFIGIRDRLV INNQEEPIMD TLPGIIIENL NMFDRYNVGI YMPFYVKEDI
TIVCTCESSK DSEAITPYLK IHVKANNSFN KEGEFIKGCD YGNNKGKHQF LTNTLKQEEN
FLCEINANPG EVVGMNCINF EEYTTTTTIN NKKKKHQNKN NKNNFDVIQL RPPHCFSNVS
ISMSFLRVVT MNVNNLLPEA KYYPEVYSFP KDKKFQKYST ISYLWIPENV PHDILFYCHC
NFPQGKGIGL FNINKTVES
