PF38_PLAF7
ID PF38_PLAF7 Reviewed; 349 AA.
AC Q8I423;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Merozoite surface protein P38;
DE Flags: Precursor;
GN Name=PFS38; Synonyms=PF38; ORFNames=PFE0395c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=16203726; DOI=10.1074/jbc.m509631200;
RA Sanders P.R., Gilson P.R., Cantin G.T., Greenbaum D.C., Nebl T.,
RA Carucci D.J., McConville M.J., Schofield L., Hodder A.N., Yates J.R. III,
RA Crabb B.S.;
RT "Distinct protein classes including novel merozoite surface antigens in
RT Raft-like membranes of Plasmodium falciparum.";
RL J. Biol. Chem. 280:40169-40176(2005).
RN [4]
RP GPI-ANCHOR.
RX PubMed=16603573; DOI=10.1074/mcp.m600035-mcp200;
RA Gilson P.R., Nebl T., Vukcevic D., Moritz R.L., Sargeant T., Speed T.P.,
RA Schofield L., Crabb B.S.;
RT "Identification and stoichiometry of glycosylphosphatidylinositol-anchored
RT membrane proteins of the human malaria parasite Plasmodium falciparum.";
RL Mol. Cell. Proteomics 5:1286-1299(2006).
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:16203726}. Cell
CC membrane {ECO:0000269|PubMed:16203726}; Lipid-anchor, GPI-anchor
CC {ECO:0000269|PubMed:16203726}. Note=Present on the surface of
CC merozoite.
CC -!- DEVELOPMENTAL STAGE: Localizes to the merozoite surface. Mostly
CC concentrated in secretory organelles at the apical end of the parasite,
CC exclusively at an early stage of schizont development. Probably
CC localizes in the rhoptry organelles. {ECO:0000269|PubMed:16203726}.
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DR EMBL; AL844504; CAD51445.1; -; Genomic_DNA.
DR RefSeq; XP_001351638.1; XM_001351602.1.
DR AlphaFoldDB; Q8I423; -.
DR SMR; Q8I423; -.
DR BioGRID; 1208187; 1.
DR IntAct; Q8I423; 1.
DR STRING; 5833.PFE0395c; -.
DR SwissPalm; Q8I423; -.
DR PRIDE; Q8I423; -.
DR EnsemblProtists; CAD51445; CAD51445; PF3D7_0508000.
DR GeneID; 812868; -.
DR KEGG; pfa:PF3D7_0508000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0508000; -.
DR HOGENOM; CLU_781861_0_0_1; -.
DR InParanoid; Q8I423; -.
DR OMA; MMNVYIN; -.
DR PhylomeDB; Q8I423; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0046658; C:anchored component of plasma membrane; IDA:GeneDB.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.2860; -; 2.
DR InterPro; IPR010884; 6_CYS_dom.
DR InterPro; IPR038160; 6_CYS_dom_sf.
DR Pfam; PF07422; s48_45; 1.
DR SMART; SM00970; s48_45; 1.
DR PROSITE; PS51701; 6_CYS; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Malaria; Membrane; Reference proteome; Repeat; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..315
FT /note="Merozoite surface protein P38"
FT /id="PRO_0000423566"
FT PROPEP 316..349
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000423567"
FT DOMAIN 22..149
FT /note="6-Cys 1"
FT DOMAIN 153..301
FT /note="6-Cys 2"
FT LIPID 315
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 77..127
FT /evidence="ECO:0000250"
FT DISULFID 157..183
FT /evidence="ECO:0000250"
FT DISULFID 197..278
FT /evidence="ECO:0000250"
FT DISULFID 208..276
FT /evidence="ECO:0000250"
SQ SEQUENCE 349 AA; 40587 MW; 2390CB23EE008E5C CRC64;
MKRWSIITGI VIIFCILTCK GQVENKKVDF RTEKGKFVPL NLVPGDVVEY SCPYSLNNDI
RNMNGVEREH FDNKKFCFDY IFVGSKLTFL KEYVRGSYNV VHKEEGNLYT SQFSVPPVVL
THRNFDCFCY MEENNVVVKK VLRIHISNGV LRKIPGCDFN ADYKESTAIT TFSNMSPRRV
KVCDVYPKSG DFISLMCPSD YSIKPDGCFS NVYVKRYPNE EVKEEDRFNL NRKWDASKYN
VVSIETVLKM NMITQGDKYS IFSKLPDVKD QVDFTCICQS NDEQDNLMMN VYINNTSYLT
NNTRSIGVNK HSFSNSEIFE RIEREEISFA FSSYLSITLI LLYLFFLNF
