ID   PFD1_BOVIN              Reviewed;         122 AA.
AC   Q3SZE2;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Prefoldin subunit 1;
GN   Name=PFDN1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Pancreas;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; BC102924; AAI02925.1; -; mRNA.
DR   RefSeq; NP_001071530.1; NM_001078062.1.
DR   AlphaFoldDB; Q3SZE2; -.
DR   SMR; Q3SZE2; -.
DR   STRING; 9913.ENSBTAP00000022078; -.
DR   PaxDb; Q3SZE2; -.
DR   PRIDE; Q3SZE2; -.
DR   Ensembl; ENSBTAT00000073542; ENSBTAP00000064720; ENSBTAG00000051779.
DR   GeneID; 616553; -.
DR   KEGG; bta:616553; -.
DR   CTD; 5201; -.
DR   VEuPathDB; HostDB:ENSBTAG00000051779; -.
DR   VGNC; VGNC:32766; PFDN1.
DR   eggNOG; KOG3501; Eukaryota.
DR   GeneTree; ENSGT00390000009786; -.
DR   HOGENOM; CLU_122140_2_0_1; -.
DR   InParanoid; Q3SZE2; -.
DR   OMA; HKNSREH; -.
DR   OrthoDB; 1492856at2759; -.
DR   TreeFam; TF106490; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000051779; Expressed in oocyte and 108 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0016272; C:prefoldin complex; IEA:Ensembl.
DR   GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR   GO; GO:0044183; F:protein folding chaperone; IEA:Ensembl.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:Ensembl.
DR   GO; GO:1905907; P:negative regulation of amyloid fibril formation; IEA:Ensembl.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR009053; Prefoldin.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O60925"
FT   CHAIN           2..122
FT                   /note="Prefoldin subunit 1"
FT                   /id="PRO_0000232445"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O60925"
SQ   SEQUENCE   122 AA;  14223 MW;  C7183F8917FD8820 CRC64;
     MAAPVDLELK KAFTELQAKV IDTQQKVKLA DVQIEQLNRT KKHAHLTDTE IMTLVDETNM
     YEGVGRMFIL QSKEAIHNQL LEKQKIAEEK IKELEQKKSY LERSVKEAED NIREMLMARR
     AQ