PFD1_CAEEL
ID PFD1_CAEEL Reviewed; 117 AA.
AC Q17827; E9P871;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Probable prefoldin subunit 1;
GN Name=pfd-1; ORFNames=C08F8.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=VC1013;
RX PubMed=18062952; DOI=10.1016/j.ydbio.2007.10.022;
RA Lundin V.F., Srayko M., Hyman A.A., Leroux M.R.;
RT "Efficient chaperone-mediated tubulin biogenesis is essential for cell
RT division and cell migration in C. elegans.";
RL Dev. Biol. 313:320-334(2008).
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins (By similarity). Has a role in
CC gonadogenesis. {ECO:0000250, ECO:0000269|PubMed:18062952}.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18062952}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q17827-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q17827-2; Sequence=VSP_044042;
CC -!- TISSUE SPECIFICITY: Expressed in the distal cell tip of developing
CC embryos. {ECO:0000269|PubMed:18062952}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit defects in distal cell tip
CC migration during gonadogenesis, reduced microtubule growth rate in
CC embryos, and larvae arrest and lethality.
CC {ECO:0000269|PubMed:18062952}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z73103; CAA97424.1; -; Genomic_DNA.
DR EMBL; Z73103; CBZ01774.1; -; Genomic_DNA.
DR PIR; T19098; T19098.
DR RefSeq; NP_001255540.1; NM_001268611.1. [Q17827-1]
DR RefSeq; NP_001255541.1; NM_001268612.1. [Q17827-2]
DR AlphaFoldDB; Q17827; -.
DR SMR; Q17827; -.
DR BioGRID; 43120; 6.
DR STRING; 6239.C08F8.1a; -.
DR EPD; Q17827; -.
DR PaxDb; Q17827; -.
DR PeptideAtlas; Q17827; -.
DR PRIDE; Q17827; -.
DR EnsemblMetazoa; C08F8.1a.1; C08F8.1a.1; WBGene00007443. [Q17827-1]
DR EnsemblMetazoa; C08F8.1b.1; C08F8.1b.1; WBGene00007443. [Q17827-2]
DR GeneID; 178021; -.
DR KEGG; cel:CELE_C08F8.1; -.
DR CTD; 178021; -.
DR WormBase; C08F8.1a; CE05248; WBGene00007443; pfd-1. [Q17827-1]
DR WormBase; C08F8.1b; CE45776; WBGene00007443; pfd-1. [Q17827-2]
DR eggNOG; KOG3501; Eukaryota.
DR GeneTree; ENSGT00390000009786; -.
DR HOGENOM; CLU_122140_2_1_1; -.
DR InParanoid; Q17827; -.
DR OMA; QKMRISE; -.
DR OrthoDB; 1492856at2759; -.
DR PhylomeDB; Q17827; -.
DR PRO; PR:Q17827; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007443; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0008406; P:gonad development; IMP:UniProtKB.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR009053; Prefoldin.
DR Pfam; PF01920; Prefoldin_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chaperone; Cytoplasm; Reference proteome.
FT CHAIN 1..117
FT /note="Probable prefoldin subunit 1"
FT /id="PRO_0000124832"
FT VAR_SEQ 1..37
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_044042"
SQ SEQUENCE 117 AA; 13897 MW; 321A1C5A222C4AAE CRC64;
MADEEISKAF RDLQFKTNET RMRIVQGEQN KKVNYQKMRI SESTKKNLVD LDENLKYYRS
VGRMFLLTDK PAEISRHEAE AKQSKEKIEA IEKQKDYLEK GLVEAETNLR ELIQSRR
