ID   PFD1_DANRE              Reviewed;         122 AA.
AC   Q5D016; A7MCD8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Prefoldin subunit 1;
GN   Name=pfdn1; ORFNames=zgc:110742;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Gill;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; BC090278; AAH90278.1; -; mRNA.
DR   EMBL; BC152140; AAI52141.1; -; mRNA.
DR   RefSeq; NP_001013362.1; NM_001013344.1.
DR   AlphaFoldDB; Q5D016; -.
DR   SMR; Q5D016; -.
DR   STRING; 7955.ENSDARP00000106280; -.
DR   PaxDb; Q5D016; -.
DR   PRIDE; Q5D016; -.
DR   Ensembl; ENSDART00000126621; ENSDARP00000106280; ENSDARG00000014536.
DR   GeneID; 503766; -.
DR   KEGG; dre:503766; -.
DR   CTD; 5201; -.
DR   ZFIN; ZDB-GENE-050306-50; pfdn1.
DR   eggNOG; KOG3501; Eukaryota.
DR   GeneTree; ENSGT00390000009786; -.
DR   HOGENOM; CLU_122140_2_0_1; -.
DR   InParanoid; Q5D016; -.
DR   OMA; HKNSREH; -.
DR   OrthoDB; 1492856at2759; -.
DR   PhylomeDB; Q5D016; -.
DR   TreeFam; TF106490; -.
DR   PRO; PR:Q5D016; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000014536; Expressed in mature ovarian follicle and 21 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR009053; Prefoldin.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..122
FT                   /note="Prefoldin subunit 1"
FT                   /id="PRO_0000232447"
SQ   SEQUENCE   122 AA;  13987 MW;  E00BCC8D2E049A11 CRC64;
     MAAPVDLELK KAFAELQAKM VDTQQKVKLA DLQIEQLSRV KKHANLTHGE ITSLPESTRM
     FEGAGRMFIL QSKGEISNQL LEKQKTADDK IKELEQKKTY LERSVKDAED NIREMLMSRR
     AQ