ID   PFD2_CAEBR              Reviewed;         142 AA.
AC   A8WVJ9;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Prefoldin subunit 2 {ECO:0000250|UniProtKB:Q9N5M2};
GN   Name=pfd-2 {ECO:0000312|EMBL:CAP24510.1}; ORFNames=CBG03668;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP24510.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity).
CC       {ECO:0000250|UniProtKB:Q9UHV9}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250|UniProtKB:Q9UHV9}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000255}.
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DR   EMBL; HE600948; CAP24510.1; -; Genomic_DNA.
DR   RefSeq; XP_002629947.1; XM_002629901.1.
DR   AlphaFoldDB; A8WVJ9; -.
DR   SMR; A8WVJ9; -.
DR   STRING; 6238.CBG03668; -.
DR   EnsemblMetazoa; CBG03668.1; CBG03668.1; WBGene00026479.
DR   GeneID; 8573108; -.
DR   KEGG; cbr:CBG_03668; -.
DR   CTD; 8573108; -.
DR   WormBase; CBG03668; CBP06584; WBGene00026479; Cbr-pfd-2.
DR   eggNOG; KOG4098; Eukaryota.
DR   HOGENOM; CLU_113004_0_1_1; -.
DR   InParanoid; A8WVJ9; -.
DR   OMA; RKCFRQI; -.
DR   OrthoDB; 1564069at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR027235; PFD2.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR009053; Prefoldin.
DR   PANTHER; PTHR13303; PTHR13303; 1.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   3: Inferred from homology;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Prefoldin subunit 2"
FT                   /id="PRO_0000394289"
SQ   SEQUENCE   142 AA;  16304 MW;  73A7AB64F1164776 CRC64;
     MSAAAVAQPQ ASPAEQEEQR KVVEKFKQLR DQQQEIATEV TRIEEERREI GRVLDVIKDL
     KPDQKCFRLI SDSLVEYTVK DVIPDLENNM TNLGLVSKQL NEQLVEKGKE LNQHKTAHNI
     RILSEKETQE IRKANAMGEI PK