PFD2_DROME
ID PFD2_DROME Reviewed; 143 AA.
AC Q9VTE5; C6SV13;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Probable prefoldin subunit 2 {ECO:0000312|FlyBase:FBgn0010741};
GN Name=Pfdn2 {ECO:0000312|FlyBase:FBgn0010741};
GN Synonyms=l(3)01239 {ECO:0000312|FlyBase:FBgn0010741};
GN ORFNames=CG6302 {ECO:0000312|FlyBase:FBgn0010741};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9VTE5; Q8T965: Dmel\CG15676; NbExp=3; IntAct=EBI-112583, EBI-130766;
CC Q9VTE5; Q9VJP9: Uxt; NbExp=4; IntAct=EBI-112583, EBI-155324;
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AE014296; AAF50107.1; -; Genomic_DNA.
DR EMBL; BT089005; ACT88146.1; -; mRNA.
DR RefSeq; NP_001261696.1; NM_001274767.1.
DR RefSeq; NP_729659.1; NM_168438.2.
DR AlphaFoldDB; Q9VTE5; -.
DR SMR; Q9VTE5; -.
DR BioGRID; 70104; 15.
DR DIP; DIP-22191N; -.
DR IntAct; Q9VTE5; 6.
DR STRING; 7227.FBpp0304954; -.
DR PaxDb; Q9VTE5; -.
DR PRIDE; Q9VTE5; -.
DR DNASU; 46121; -.
DR EnsemblMetazoa; FBtr0076238; FBpp0075967; FBgn0010741.
DR EnsemblMetazoa; FBtr0332708; FBpp0304954; FBgn0010741.
DR GeneID; 46121; -.
DR KEGG; dme:Dmel_CG6302; -.
DR CTD; 5202; -.
DR FlyBase; FBgn0010741; Pfdn2.
DR VEuPathDB; VectorBase:FBgn0010741; -.
DR eggNOG; KOG4098; Eukaryota.
DR GeneTree; ENSGT00390000009272; -.
DR HOGENOM; CLU_113004_0_0_1; -.
DR InParanoid; Q9VTE5; -.
DR OMA; RKCFRQI; -.
DR OrthoDB; 1564069at2759; -.
DR PhylomeDB; Q9VTE5; -.
DR BioGRID-ORCS; 46121; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 46121; -.
DR PRO; PR:Q9VTE5; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0010741; Expressed in eye disc (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9VTE5; baseline and differential.
DR Genevisible; Q9VTE5; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016272; C:prefoldin complex; IDA:FlyBase.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0045196; P:establishment or maintenance of neuroblast polarity; IMP:FlyBase.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR027235; PFD2.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR009053; Prefoldin.
DR PANTHER; PTHR13303; PTHR13303; 1.
DR Pfam; PF01920; Prefoldin_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Reference proteome.
FT CHAIN 1..143
FT /note="Probable prefoldin subunit 2"
FT /id="PRO_0000124838"
SQ SEQUENCE 143 AA; 16203 MW; CC9209FB4271DDC1 CRC64;
MSTESAKPAL SQEAIVAQFQ QLRNEQRNLV NSLNTLEMDL REHKTVIETL EAADPERKCF
RQIGGVLCER TVKEVLPQLV ENKDFIAKTI QMVTNDLSKK GSELNKFKEE HNIKIRGEHL
VAEGAKGDDA EDKAENRNVL VFN
