ID   PFD3_CAEEL              Reviewed;         185 AA.
AC   O18054;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Probable prefoldin subunit 3;
GN   Name=pfd-3; Synonyms=vbp-1; ORFNames=T06G6.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; Z81587; CAB04707.1; -; Genomic_DNA.
DR   PIR; T24621; T24621.
DR   RefSeq; NP_493228.1; NM_060827.6.
DR   AlphaFoldDB; O18054; -.
DR   SMR; O18054; -.
DR   BioGRID; 38538; 11.
DR   DIP; DIP-24979N; -.
DR   STRING; 6239.T06G6.9; -.
DR   iPTMnet; O18054; -.
DR   EPD; O18054; -.
DR   PaxDb; O18054; -.
DR   PeptideAtlas; O18054; -.
DR   EnsemblMetazoa; T06G6.9.1; T06G6.9.1; WBGene00006889.
DR   GeneID; 173141; -.
DR   KEGG; cel:CELE_T06G6.9; -.
DR   CTD; 173141; -.
DR   WormBase; T06G6.9; CE13349; WBGene00006889; pfd-3.
DR   eggNOG; KOG3313; Eukaryota.
DR   GeneTree; ENSGT00390000018904; -.
DR   HOGENOM; CLU_083737_1_0_1; -.
DR   InParanoid; O18054; -.
DR   OMA; DEQHSKY; -.
DR   OrthoDB; 1567796at2759; -.
DR   PhylomeDB; O18054; -.
DR   PRO; PR:O18054; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00006889; Expressed in germ line (C elegans) and 5 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005844; C:polysome; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR016655; PFD3.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12409; PTHR12409; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   PIRSF; PIRSF016396; Prefoldin_subunit_3; 1.
PE   3: Inferred from homology;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..185
FT                   /note="Probable prefoldin subunit 3"
FT                   /id="PRO_0000153655"
SQ   SEQUENCE   185 AA;  20885 MW;  6B2B64BABBD2AC23 CRC64;
     MSDTADSLSA RGIPKSELIE DVESWLTKEK LSIEEAEVVL REKYGKYKYV ESSMLAQKVR
     MSEKIPEFEN SLSIIDTLIA KRAADESFET TFLLSDDVYT KATVQKPEKV SIWLGANVMV
     EYDLENARKL LDKNRGSVQK VVDELTNELS YIKDQITTTE VNMSHIVNFG VNKRRAALAV
     NNGAK