ID   PFD4_BOVIN              Reviewed;         134 AA.
AC   Q2TBR6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Prefoldin subunit 4;
GN   Name=PFDN4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. Interacts with URI1; the interaction is phosphorylation-
CC       dependent and occurs in a growth-dependent manner (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; BC109756; AAI09757.1; -; mRNA.
DR   RefSeq; NP_001033629.1; NM_001038540.1.
DR   AlphaFoldDB; Q2TBR6; -.
DR   SMR; Q2TBR6; -.
DR   STRING; 9913.ENSBTAP00000011605; -.
DR   PaxDb; Q2TBR6; -.
DR   PRIDE; Q2TBR6; -.
DR   Ensembl; ENSBTAT00000011605; ENSBTAP00000011605; ENSBTAG00000008812.
DR   GeneID; 514621; -.
DR   KEGG; bta:514621; -.
DR   CTD; 5203; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008812; -.
DR   eggNOG; KOG1760; Eukaryota.
DR   GeneTree; ENSGT00390000006696; -.
DR   InParanoid; Q2TBR6; -.
DR   OMA; NARMDEF; -.
DR   OrthoDB; 1459797at2759; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000008812; Expressed in biceps femoris and 105 other tissues.
DR   ExpressionAtlas; Q2TBR6; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR016661; PFDN4.
DR   InterPro; IPR009053; Prefoldin.
DR   PANTHER; PTHR21100; PTHR21100; 1.
DR   Pfam; PF01920; Prefoldin_2; 1.
DR   PIRSF; PIRSF016477; Prefoldin_subunit_4; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Cytoplasm; Mitochondrion; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NQP4"
FT   CHAIN           2..134
FT                   /note="Prefoldin subunit 4"
FT                   /id="PRO_0000282858"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NQP4"
FT   MOD_RES         125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NQP4"
SQ   SEQUENCE   134 AA;  15328 MW;  AD8C812612443DC2 CRC64;
     MAATMKKAAA EDVNVTFEDQ QKINKFARNT SRITELKEEI EVKKKQLQNL EDACEDIMLA
     DDDCLMIPYQ IGDVFISHSQ EETQEMLEEA KKNLQEEIDA LESRVESIQR VLADLKVQLY
     AKFGSNINLE ADES