ID   PFD5_BOVIN              Reviewed;         154 AA.
AC   Q8HYI9; Q3T0V1;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Prefoldin subunit 5;
GN   Name=PFDN5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Korean;
RA   Baik M., Bong J., Kong T.;
RT   "Nucleotide sequence of bovine prefoldin 5 cDNA in adipose tissues of
RT   Korean cattle.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins. Represses the transcriptional activity
CC       of MYC (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AF520958; AAN77125.1; -; mRNA.
DR   EMBL; BC102252; AAI02253.1; -; mRNA.
DR   RefSeq; NP_777157.1; NM_174732.2.
DR   AlphaFoldDB; Q8HYI9; -.
DR   SMR; Q8HYI9; -.
DR   STRING; 9913.ENSBTAP00000011762; -.
DR   PaxDb; Q8HYI9; -.
DR   PRIDE; Q8HYI9; -.
DR   Ensembl; ENSBTAT00000081994; ENSBTAP00000061773; ENSBTAG00000008935.
DR   GeneID; 282848; -.
DR   KEGG; bta:282848; -.
DR   CTD; 5204; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008935; -.
DR   VGNC; VGNC:32767; PFDN5.
DR   eggNOG; KOG3048; Eukaryota.
DR   GeneTree; ENSGT00390000008783; -.
DR   HOGENOM; CLU_091867_0_1_1; -.
DR   InParanoid; Q8HYI9; -.
DR   OMA; QAKFKAC; -.
DR   OrthoDB; 1449403at2759; -.
DR   TreeFam; TF106509; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000008935; Expressed in oviduct epithelium and 106 other tissues.
DR   ExpressionAtlas; Q8HYI9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:Ensembl.
DR   GO; GO:1905907; P:negative regulation of amyloid fibril formation; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0006457; P:protein folding; IEA:Ensembl.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Chaperone; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q99471"
FT   CHAIN           2..154
FT                   /note="Prefoldin subunit 5"
FT                   /id="PRO_0000153660"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99471"
FT   MOD_RES         42
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99471"
SQ   SEQUENCE   154 AA;  17385 MW;  8CB2E3C453412FDA CRC64;
     MAQSVNITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLKKNNEGK
     ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA
     LQEKHAMKQA VMEMMSQKIQ QLTTLGAAQA TAKA