ID   PFD5_DROME              Reviewed;         168 AA.
AC   Q9VCZ8;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Probable prefoldin subunit 5;
GN   Name=Pfdn5 {ECO:0000312|FlyBase:FBgn0038976};
GN   ORFNames=CG7048 {ECO:0000312|FlyBase:FBgn0038976};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Head;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9VCZ8; Q8T965: Dmel\CG15676; NbExp=4; IntAct=EBI-100243, EBI-130766;
CC       Q9VCZ8; Q9VGP6: mgr; NbExp=4; IntAct=EBI-100243, EBI-186707;
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AE014297; AAF56007.1; -; Genomic_DNA.
DR   EMBL; AY051649; AAK93073.1; -; mRNA.
DR   RefSeq; NP_001163688.1; NM_001170217.2.
DR   RefSeq; NP_651053.1; NM_142796.4.
DR   AlphaFoldDB; Q9VCZ8; -.
DR   SMR; Q9VCZ8; -.
DR   BioGRID; 67602; 15.
DR   DIP; DIP-20776N; -.
DR   IntAct; Q9VCZ8; 9.
DR   STRING; 7227.FBpp0290701; -.
DR   PaxDb; Q9VCZ8; -.
DR   PRIDE; Q9VCZ8; -.
DR   DNASU; 42647; -.
DR   EnsemblMetazoa; FBtr0084257; FBpp0083650; FBgn0038976.
DR   EnsemblMetazoa; FBtr0301486; FBpp0290701; FBgn0038976.
DR   GeneID; 42647; -.
DR   KEGG; dme:Dmel_CG7048; -.
DR   UCSC; CG7048-RA; d. melanogaster.
DR   CTD; 5204; -.
DR   FlyBase; FBgn0038976; Pfdn5.
DR   VEuPathDB; VectorBase:FBgn0038976; -.
DR   eggNOG; KOG3048; Eukaryota.
DR   GeneTree; ENSGT00390000008783; -.
DR   HOGENOM; CLU_091867_0_1_1; -.
DR   InParanoid; Q9VCZ8; -.
DR   OMA; QAKFKAC; -.
DR   OrthoDB; 1449403at2759; -.
DR   PhylomeDB; Q9VCZ8; -.
DR   SignaLink; Q9VCZ8; -.
DR   BioGRID-ORCS; 42647; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; CG7048; fly.
DR   GenomeRNAi; 42647; -.
DR   PRO; PR:Q9VCZ8; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0038976; Expressed in testis and 21 other tissues.
DR   ExpressionAtlas; Q9VCZ8; baseline and differential.
DR   Genevisible; Q9VCZ8; DM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IDA:FlyBase.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; ISS:FlyBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Reference proteome.
FT   CHAIN           1..168
FT                   /note="Probable prefoldin subunit 5"
FT                   /id="PRO_0000153665"
SQ   SEQUENCE   168 AA;  19078 MW;  047C81F16AD59194 CRC64;
     MAATPSAPAK SEMIDLTKLS PEQLIQIKQE FEQEITNVQD SLSTLHGCQA KYAGSKEALG
     TFQPNWENRQ ILVPLTSSMY VPGRVKDLNR FVIDIGTGYY IEKDLEGSKD YFKRRVEYVQ
     EQIEKIEKIH LQKTRFYNSV MSVLEMKQAA AAKLQSQQQS QPAVTQSS