PFD6_BOVIN
ID PFD6_BOVIN Reviewed; 129 AA.
AC Q17Q89;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Prefoldin subunit 6;
GN Name=PFDN6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC transfers target proteins to it. Binds to nascent polypeptide chain and
CC promotes folding in an environment in which there are many competing
CC pathways for nonnative proteins. {ECO:0000250|UniProtKB:O15212}.
CC -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC subunits (By similarity). Component of the PAQosome complex which is
CC responsible for the biogenesis of several protein complexes and which
CC consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI
CC complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF,
CC POLR2E and DNAAF10/WDR92 (By similarity).
CC {ECO:0000250|UniProtKB:O15212, ECO:0000250|UniProtKB:P52553}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC {ECO:0000305}.
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DR EMBL; BC118486; AAI18487.1; -; mRNA.
DR RefSeq; NP_001068889.1; NM_001075421.2.
DR RefSeq; XP_005223280.1; XM_005223223.3.
DR RefSeq; XP_005223281.1; XM_005223224.3.
DR RefSeq; XP_010816333.1; XM_010818031.2.
DR AlphaFoldDB; Q17Q89; -.
DR SMR; Q17Q89; -.
DR STRING; 9913.ENSBTAP00000022382; -.
DR PaxDb; Q17Q89; -.
DR PeptideAtlas; Q17Q89; -.
DR PRIDE; Q17Q89; -.
DR Ensembl; ENSBTAT00000022382; ENSBTAP00000022382; ENSBTAG00000010723.
DR GeneID; 509914; -.
DR KEGG; bta:509914; -.
DR CTD; 10471; -.
DR VEuPathDB; HostDB:ENSBTAG00000010723; -.
DR VGNC; VGNC:32768; PFDN6.
DR eggNOG; KOG3478; Eukaryota.
DR GeneTree; ENSGT00390000010512; -.
DR HOGENOM; CLU_125172_0_1_1; -.
DR InParanoid; Q17Q89; -.
DR OMA; VQTEFAQ; -.
DR OrthoDB; 1559044at2759; -.
DR TreeFam; TF315166; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000010723; Expressed in pons and 103 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; IEA:Ensembl.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:Ensembl.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; IBA:GO_Central.
DR GO; GO:1905907; P:negative regulation of amyloid fibril formation; IEA:Ensembl.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR InterPro; IPR002777; PFD_beta-like.
DR InterPro; IPR009053; Prefoldin.
DR Pfam; PF01920; Prefoldin_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Chaperone; Isopeptide bond; Reference proteome;
KW Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O15212"
FT CHAIN 2..129
FT /note="Prefoldin subunit 6"
FT /id="PRO_0000282859"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O15212"
FT MOD_RES 21
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O15212"
FT MOD_RES 66
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:O15212"
FT CROSSLNK 66
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1); alternate"
FT /evidence="ECO:0000250|UniProtKB:O15212"
FT CROSSLNK 66
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:O15212"
SQ SEQUENCE 129 AA; 14555 MW; A0C38EAAE512A022 CRC64;
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL DGSNVVFKLL
GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLEQQ SEQQRETLAQ LQQEFQRAQA
AKAGAPGKA