ID   PFD6_CAEEL              Reviewed;         126 AA.
AC   P52554;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Probable prefoldin subunit 6;
GN   Name=pfd-6; ORFNames=F21C3.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=11099033; DOI=10.1038/35042517;
RA   Fraser A.G., Kamath R.S., Zipperlen P., Martinez-Campos M., Sohrmann M.,
RA   Ahringer J.;
RT   "Functional genomic analysis of C. elegans chromosome I by systematic RNA
RT   interference.";
RL   Nature 408:325-330(2000).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=18062952; DOI=10.1016/j.ydbio.2007.10.022;
RA   Lundin V.F., Srayko M., Hyman A.A., Leroux M.R.;
RT   "Efficient chaperone-mediated tubulin biogenesis is essential for cell
RT   division and cell migration in C. elegans.";
RL   Dev. Biol. 313:320-334(2008).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). Required for
CC       positioning of the mitotic spindle. {ECO:0000250,
CC       ECO:0000269|PubMed:18062952}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18062952}.
CC   -!- TISSUE SPECIFICITY: Expressed in embryonic blastomeres and gonads.
CC       {ECO:0000269|PubMed:18062952}.
CC   -!- DISRUPTION PHENOTYPE: Abnormal locomotion, abnormal morphology, slow
CC       growth, defects in distal tip cell migration, defects in developing
CC       gonads, and in extreme cases embryonic lethal.
CC       {ECO:0000269|PubMed:11099033, ECO:0000269|PubMed:18062952}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; Z71261; CAA95804.1; -; Genomic_DNA.
DR   PIR; T21191; T21191.
DR   RefSeq; NP_492058.1; NM_059657.4.
DR   AlphaFoldDB; P52554; -.
DR   SMR; P52554; -.
DR   BioGRID; 37916; 20.
DR   IntAct; P52554; 1.
DR   STRING; 6239.F21C3.5; -.
DR   EPD; P52554; -.
DR   PaxDb; P52554; -.
DR   PeptideAtlas; P52554; -.
DR   PRIDE; P52554; -.
DR   EnsemblMetazoa; F21C3.5.1; F21C3.5.1; WBGene00009004.
DR   GeneID; 172474; -.
DR   KEGG; cel:CELE_F21C3.5; -.
DR   CTD; 172474; -.
DR   WormBase; F21C3.5; CE05680; WBGene00009004; pfd-6.
DR   eggNOG; KOG3478; Eukaryota.
DR   GeneTree; ENSGT00390000010512; -.
DR   HOGENOM; CLU_125172_0_1_1; -.
DR   InParanoid; P52554; -.
DR   OMA; VQTEFAQ; -.
DR   OrthoDB; 1559044at2759; -.
DR   PhylomeDB; P52554; -.
DR   PRO; PR:P52554; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00009004; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR009053; Prefoldin.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..126
FT                   /note="Probable prefoldin subunit 6"
FT                   /id="PRO_0000124852"
SQ   SEQUENCE   126 AA;  14737 MW;  7EE42114C958B4EF CRC64;
     MADMAKFEEE VNKLRTLEKD REKYFTSRQE MEMRLTESKN VKAELDLMES DSKVYKLIGA
     VLVRQDLEEA RSTVEKRLEF IDSETKRVEA SISDISKKCT EQRDKVMNMQ KSFQMMAQAA
     AQAQKK