ID   PFD6_PLAF7              Reviewed;         119 AA.
AC   Q8I3Y6; C0H4D4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable prefoldin subunit 6;
GN   ORFNames=PFE0595w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000305}
RP   SYNTHESIS OF 1-33, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-helical
RT   coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and
CC       transfers target proteins to it. Binds to nascent polypeptide chain and
CC       promotes folding in an environment in which there are many competing
CC       pathways for nonnative proteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type
CC       subunits. {ECO:0000250|UniProtKB:O15212}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC       determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000255}.
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DR   EMBL; AL844504; CAX63956.1; -; Genomic_DNA.
DR   RefSeq; XP_002808685.1; XM_002808639.1.
DR   AlphaFoldDB; Q8I3Y6; -.
DR   SMR; Q8I3Y6; -.
DR   BioGRID; 1208251; 2.
DR   IntAct; Q8I3Y6; 2.
DR   STRING; 5833.PFE0595w; -.
DR   PRIDE; Q8I3Y6; -.
DR   EnsemblProtists; CAX63956; CAX63956; PF3D7_0512000.
DR   GeneID; 812934; -.
DR   KEGG; pfa:PF3D7_0512000; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0512000; -.
DR   HOGENOM; CLU_125172_2_0_1; -.
DR   InParanoid; Q8I3Y6; -.
DR   OMA; REQTIVH; -.
DR   PhylomeDB; Q8I3Y6; -.
DR   Proteomes; UP000001450; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; ISS:UniProtKB.
DR   GO; GO:0051087; F:chaperone binding; ISS:UniProtKB.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISS:UniProtKB.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   InterPro; IPR009053; Prefoldin.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Merozoite; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Probable prefoldin subunit 6"
FT                   /id="PRO_0000370213"
SQ   SEQUENCE   119 AA;  13667 MW;  AC825169CD829755 CRC64;
     MSQEKISEII KDISALKTSC EKLNSQLDEL ITQKVENEML LEEVKVLEDD SVLHKLVGLV
     LVKEEKSKCY DTISRRLQYI TGEIENRKKV ITNSEEKLRK LFSDLEAHAG QRKIPVPQA