PFDA1_THEKO
ID PFDA1_THEKO Reviewed; 146 AA.
AC Q5JIE3;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Prefoldin subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00308};
DE AltName: Full=GimC subunit alpha 1 {ECO:0000255|HAMAP-Rule:MF_00308};
GN Name=pfdA1 {ECO:0000255|HAMAP-Rule:MF_00308}; OrderedLocusNames=TK1005;
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC archaeal de novo protein folding. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC {ECO:0000305}.
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DR EMBL; AP006878; BAD85194.1; -; Genomic_DNA.
DR RefSeq; WP_011249956.1; NC_006624.1.
DR AlphaFoldDB; Q5JIE3; -.
DR SMR; Q5JIE3; -.
DR STRING; 69014.TK1005; -.
DR EnsemblBacteria; BAD85194; BAD85194; TK1005.
DR GeneID; 3234318; -.
DR KEGG; tko:TK1005; -.
DR PATRIC; fig|69014.16.peg.983; -.
DR eggNOG; arCOG01341; Archaea.
DR HOGENOM; CLU_091867_1_3_2; -.
DR InParanoid; Q5JIE3; -.
DR OMA; ELQNQFM; -.
DR OrthoDB; 111673at2157; -.
DR PhylomeDB; Q5JIE3; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR PANTHER; PTHR12674; PTHR12674; 1.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Reference proteome.
FT CHAIN 1..146
FT /note="Prefoldin subunit alpha 1"
FT /id="PRO_0000153685"
SQ SEQUENCE 146 AA; 16275 MW; 19DCAD3BA7F7B02C CRC64;
MAEDTKKLEE LAYQYQLLQA QAQLLAQNLE LLTLGRNEFQ AVKETLEGLK NEEGEFEILV
PIGAGSFLKG KIVDAKNAIV SVGAGYAVQK SLDDSIEYLE KRIKEYEEAI AKTQEALKKL
EAQLGELARQ AQEIQQKQAM GFSVKK