ID   PFDA2_THEKO             Reviewed;         142 AA.
AC   Q5JE63;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Prefoldin subunit alpha 2 {ECO:0000255|HAMAP-Rule:MF_00308};
DE   AltName: Full=GimC subunit alpha 2 {ECO:0000255|HAMAP-Rule:MF_00308};
GN   Name=pfdA2 {ECO:0000255|HAMAP-Rule:MF_00308}; OrderedLocusNames=TK1121;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC       archaeal de novo protein folding. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC   -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00308}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AP006878; BAD85310.1; -; Genomic_DNA.
DR   RefSeq; WP_011250072.1; NC_006624.1.
DR   AlphaFoldDB; Q5JE63; -.
DR   SMR; Q5JE63; -.
DR   STRING; 69014.TK1121; -.
DR   EnsemblBacteria; BAD85310; BAD85310; TK1121.
DR   GeneID; 3235585; -.
DR   KEGG; tko:TK1121; -.
DR   PATRIC; fig|69014.16.peg.1098; -.
DR   eggNOG; arCOG01341; Archaea.
DR   HOGENOM; CLU_091867_1_3_2; -.
DR   InParanoid; Q5JE63; -.
DR   OMA; RGYMANI; -.
DR   OrthoDB; 100215at2157; -.
DR   PhylomeDB; Q5JE63; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Prefoldin subunit alpha 2"
FT                   /id="PRO_0000153686"
SQ   SEQUENCE   142 AA;  16097 MW;  7D6992BF82030B70 CRC64;
     MAEEKKTRTL EQIQDEIRSY LGEIEYLRSQ VGVIDATITD LRTVDATLAY LKEKGKGKEI
     YIPLGSGVAI RGKIENPDDV IMDVGAGILV GATVDEAREN IEKRIKALMD LRLALLRKIE
     EDTRKVNELL KELQEMQPEK RE