ID   PFDA_AQUAE              Reviewed;         149 AA.
AC   O66961;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative prefoldin subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
GN   OrderedLocusNames=aq_759;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AE000657; AAC06929.1; -; Genomic_DNA.
DR   PIR; F70366; F70366.
DR   RefSeq; NP_213522.1; NC_000918.1.
DR   RefSeq; WP_010880460.1; NC_000918.1.
DR   AlphaFoldDB; O66961; -.
DR   SMR; O66961; -.
DR   STRING; 224324.aq_759; -.
DR   EnsemblBacteria; AAC06929; AAC06929; aq_759.
DR   KEGG; aae:aq_759; -.
DR   eggNOG; COG1730; Bacteria.
DR   HOGENOM; CLU_091867_1_3_0; -.
DR   InParanoid; O66961; -.
DR   OMA; RGYMANI; -.
DR   OrthoDB; 2043138at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Putative prefoldin subunit alpha"
FT                   /id="PRO_0000153692"
SQ   SEQUENCE   149 AA;  16598 MW;  79FEE9A36836777C CRC64;
     MAEEKKEVQK TPEQKMDELN RQLRGYMANI EALRAEISVI NQSITDLRTA EATLRSLKEL
     GKGKEVLIPV GATAQIKAKS EGVDEVIMSI GTGISAVMSY DEAVDRIRKE IAALEALRRA
     LEEAIADLYN KIEELLEEVR KVGQEEAKK