ID   PFDA_HALSA              Reviewed;         154 AA.
AC   Q9HMN2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Prefoldin subunit alpha;
DE   AltName: Full=GimC subunit alpha;
GN   Name=pfdA; OrderedLocusNames=VNG_2465C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC       archaeal de novo protein folding (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG20539.1; -; Genomic_DNA.
DR   PIR; G84396; G84396.
DR   RefSeq; WP_010903841.1; NC_002607.1.
DR   AlphaFoldDB; Q9HMN2; -.
DR   SMR; Q9HMN2; -.
DR   STRING; 64091.VNG_2465C; -.
DR   PaxDb; Q9HMN2; -.
DR   EnsemblBacteria; AAG20539; AAG20539; VNG_2465C.
DR   GeneID; 5953761; -.
DR   GeneID; 62887705; -.
DR   KEGG; hal:VNG_2465C; -.
DR   PATRIC; fig|64091.14.peg.1907; -.
DR   HOGENOM; CLU_091867_1_3_2; -.
DR   InParanoid; Q9HMN2; -.
DR   OMA; ELQNQFM; -.
DR   OrthoDB; 105878at2157; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..154
FT                   /note="Prefoldin subunit alpha"
FT                   /id="PRO_0000153672"
FT   REGION          123..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   154 AA;  16704 MW;  7F8E6F03AE0D7A07 CRC64;
     MSLGGGGQQQ LQQLSQEIQA IEEEVEELEA DVASLRQEQT EIEEAKEALD VLETGATVQV
     PLGGDAYVRA EVKDMDEVVV SLGGGYAAEQ DSDAAASVLD EKKATIDGRI DDVQAEIADL
     SEEAEQLEQQ AQQAQQQMMQ QQMQAQQQPQ DGEQ