PFDA_METB6
ID PFDA_METB6 Reviewed; 153 AA.
AC A7I9I3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Prefoldin subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
DE AltName: Full=GimC subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
GN Name=pfdA {ECO:0000255|HAMAP-Rule:MF_00308}; OrderedLocusNames=Mboo_1879;
OS Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=456442;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21154 / JCM 14090 / 6A8;
RX PubMed=25998264; DOI=10.1099/mic.0.000117;
RA Braeuer S., Cadillo-Quiroz H., Kyrpides N., Woyke T., Goodwin L.,
RA Detter C., Podell S., Yavitt J.B., Zinder S.H.;
RT "Genome of Methanoregula boonei 6A8 reveals adaptations to oligotrophic
RT peatland environments.";
RL Microbiology 161:1572-1581(2015).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC archaeal de novo protein folding. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SIMILARITY: Belongs to the prefoldin alpha subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABS56394.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000780; ABS56394.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_052291926.1; NC_009712.1.
DR AlphaFoldDB; A7I9I3; -.
DR SMR; A7I9I3; -.
DR STRING; 456442.Mboo_1879; -.
DR EnsemblBacteria; ABS56394; ABS56394; Mboo_1879.
DR GeneID; 5411373; -.
DR KEGG; mbn:Mboo_1879; -.
DR eggNOG; arCOG01341; Archaea.
DR HOGENOM; CLU_091867_1_3_2; -.
DR Proteomes; UP000002408; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.370; -; 1.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Reference proteome.
FT CHAIN 1..153
FT /note="Prefoldin subunit alpha"
FT /id="PRO_0000322255"
FT REGION 126..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 153 AA; 17016 MW; 21C64FD4776669E0 CRC64;
MDQNEIETLQ YYLKEYGQQA EVFAGQLELM ENGRMEALAA IEALEALATS EDGTVLLQIG
GGASLRAKVL EPEKVLLNIG SEVIVEKTSV DAIEYLKDRI TELEASQKKV SEALEKLRAQ
TNEIAKRLEQ GYRQAPGGSP VPHRHDHEDH DEE