PFDA_METMJ
ID PFDA_METMJ Reviewed; 149 AA.
AC A3CWZ2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Prefoldin subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
DE AltName: Full=GimC subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
GN Name=pfdA {ECO:0000255|HAMAP-Rule:MF_00308}; OrderedLocusNames=Memar_1966;
OS Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=368407;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35101 / DSM 1498 / JR1;
RX PubMed=21304656; DOI=10.4056/sigs.32535;
RA Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT type strain JR1.";
RL Stand. Genomic Sci. 1:189-196(2009).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC archaeal de novo protein folding. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SIMILARITY: Belongs to the prefoldin alpha subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
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DR EMBL; CP000562; ABN57892.1; -; Genomic_DNA.
DR RefSeq; WP_011844801.1; NC_009051.1.
DR AlphaFoldDB; A3CWZ2; -.
DR SMR; A3CWZ2; -.
DR STRING; 368407.Memar_1966; -.
DR EnsemblBacteria; ABN57892; ABN57892; Memar_1966.
DR GeneID; 4847712; -.
DR KEGG; mem:Memar_1966; -.
DR eggNOG; arCOG01341; Archaea.
DR HOGENOM; CLU_091867_1_3_2; -.
DR OMA; ELQNQFM; -.
DR OrthoDB; 108984at2157; -.
DR Proteomes; UP000002146; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.370; -; 1.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR PANTHER; PTHR12674; PTHR12674; 1.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm.
FT CHAIN 1..149
FT /note="Prefoldin subunit alpha"
FT /id="PRO_0000322254"
SQ SEQUENCE 149 AA; 16041 MW; C0DC6A824BA28A6C CRC64;
MDQADPREIQ TLQMYLNEYG QQIELMTQQL SMIEQQRLEG TAAIETLRAL QENADGAVLL
PIGGGAYLRV KVLDAGHVLV NIGADVSVER ATADAVGYLE DRITELEALA KKVAGSVEQL
QGQATEISRR LEAAYRGARQ AQAGQGGSS