PFDA_METS3
ID PFDA_METS3 Reviewed; 146 AA.
AC A5UL29;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Prefoldin subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
DE AltName: Full=GimC subunit alpha {ECO:0000255|HAMAP-Rule:MF_00308};
GN Name=pfdA {ECO:0000255|HAMAP-Rule:MF_00308}; OrderedLocusNames=Msm_0702;
OS Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=420247;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35061 / DSM 861 / OCM 144 / PS;
RX PubMed=17563350; DOI=10.1073/pnas.0704189104;
RA Samuel B.S., Hansen E.E., Manchester J.K., Coutinho P.M., Henrissat B.,
RA Fulton R., Latreille P., Kim K., Wilson R.K., Gordon J.I.;
RT "Genomic and metabolic adaptations of Methanobrevibacter smithii to the
RT human gut.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:10643-10648(2007).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC archaeal de novo protein folding. {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00308}.
CC -!- SIMILARITY: Belongs to the prefoldin alpha subunit family.
CC {ECO:0000255|HAMAP-Rule:MF_00308}.
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DR EMBL; CP000678; ABQ86907.1; -; Genomic_DNA.
DR RefSeq; WP_011954057.1; NC_009515.1.
DR AlphaFoldDB; A5UL29; -.
DR SMR; A5UL29; -.
DR STRING; 420247.Msm_0702; -.
DR EnsemblBacteria; ABQ86907; ABQ86907; Msm_0702.
DR GeneID; 5217271; -.
DR KEGG; msi:Msm_0702; -.
DR PATRIC; fig|420247.28.peg.699; -.
DR eggNOG; arCOG01341; Archaea.
DR HOGENOM; CLU_091867_1_1_2; -.
DR OMA; ELQNQFM; -.
DR Proteomes; UP000001992; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.370; -; 1.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR PANTHER; PTHR12674; PTHR12674; 1.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm.
FT CHAIN 1..146
FT /note="Prefoldin subunit alpha"
FT /id="PRO_0000322252"
SQ SEQUENCE 146 AA; 15649 MW; 03B38BAB1C8E7E6E CRC64;
MEGQQKFNQL LNEINVYKQQ GDLIQQQIEL VRASIAEVDA LTNTLDDLEG KDSVEAFVPV
GAGSFIKGEL KNTDEVIVSI GSGIAVKKDV DGARETIARQ KKDLEDSLDK MLANMQQVSD
IIGSLSAQAE QLAAVAQGNM SATGLN