ID   PFDA_PYRAB              Reviewed;         148 AA.
AC   Q9UYI4; G8ZIU4;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Prefoldin subunit alpha;
DE   AltName: Full=GimC subunit alpha;
GN   Name=pfdA; OrderedLocusNames=PYRAB15230; ORFNames=PAB1006;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC       proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC       archaeal de novo protein folding (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; AJ248287; CAB50428.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE70977.1; -; Genomic_DNA.
DR   PIR; G75066; G75066.
DR   RefSeq; WP_010868641.1; NC_000868.1.
DR   AlphaFoldDB; Q9UYI4; -.
DR   SMR; Q9UYI4; -.
DR   STRING; 272844.PAB1006; -.
DR   PRIDE; Q9UYI4; -.
DR   EnsemblBacteria; CAB50428; CAB50428; PAB1006.
DR   GeneID; 1495806; -.
DR   KEGG; pab:PAB1006; -.
DR   PATRIC; fig|272844.11.peg.1622; -.
DR   eggNOG; arCOG01341; Archaea.
DR   HOGENOM; CLU_091867_1_3_2; -.
DR   OMA; ELQNQFM; -.
DR   OrthoDB; 112405at2157; -.
DR   PhylomeDB; Q9UYI4; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016272; C:prefoldin complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.370; -; 1.
DR   HAMAP; MF_00308; PfdA; 1.
DR   InterPro; IPR011599; PFD_alpha_archaea.
DR   InterPro; IPR009053; Prefoldin.
DR   InterPro; IPR004127; Prefoldin_subunit_alpha.
DR   PANTHER; PTHR12674; PTHR12674; 1.
DR   Pfam; PF02996; Prefoldin; 1.
DR   TIGRFAMs; TIGR00293; TIGR00293; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm.
FT   CHAIN           1..148
FT                   /note="Prefoldin subunit alpha"
FT                   /id="PRO_0000153681"
SQ   SEQUENCE   148 AA;  16561 MW;  DCE05593AF2EA1B8 CRC64;
     MAQSNKELEK LAYEYQLLQA QAQLLAQNLE LLNLARAEVQ TVKETLENLK KIEEEKPEIL
     VPIGAGSFLK GIIVDKNNAI VSVGSGYAVE RSVDDAISFL EKRLNEYDDA IKKTQQALTE
     LEKRLGDVAK KAQEIQQKQA MGSFKVKK