PFDA_PYRAE
ID PFDA_PYRAE Reviewed; 132 AA.
AC Q8ZTT9;
DT 13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Prefoldin subunit alpha;
DE AltName: Full=GimC subunit alpha;
GN Name=pfdA; OrderedLocusNames=PAE3099;
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- FUNCTION: Molecular chaperone capable of stabilizing a range of
CC proteins. Seems to fulfill an ATP-independent, HSP70-like function in
CC archaeal de novo protein folding (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterohexamer of two alpha and four beta subunits.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the prefoldin subunit alpha family.
CC {ECO:0000305}.
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DR EMBL; AE009441; AAL64670.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZTT9; -.
DR SMR; Q8ZTT9; -.
DR STRING; 178306.PAE3099; -.
DR EnsemblBacteria; AAL64670; AAL64670; PAE3099.
DR KEGG; pai:PAE3099; -.
DR PATRIC; fig|178306.9.peg.2329; -.
DR eggNOG; arCOG01341; Archaea.
DR HOGENOM; CLU_1912415_0_0_2; -.
DR InParanoid; Q8ZTT9; -.
DR OMA; RYVHIGA; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016272; C:prefoldin complex; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.287.370; -; 1.
DR HAMAP; MF_00308; PfdA; 1.
DR InterPro; IPR011599; PFD_alpha_archaea.
DR InterPro; IPR009053; Prefoldin.
DR InterPro; IPR004127; Prefoldin_subunit_alpha.
DR Pfam; PF02996; Prefoldin; 1.
DR TIGRFAMs; TIGR00293; TIGR00293; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Reference proteome.
FT CHAIN 1..132
FT /note="Prefoldin subunit alpha"
FT /id="PRO_0000153682"
SQ SEQUENCE 132 AA; 14750 MW; BC12A53F8F9D53F1 CRC64;
MSRQDVQRLL EEYQLIGELL SSLQAQHATV AELLEELTTA LDGVRLLKGE GGERLVHIGA
GLFVKGVFEA KEVLAPLGAG YHAFLDLNNA ERILQERIEE YSKLKTSLEE NIEKLAERAA
QIRQALERLG IR