PFEA_PSEAE
ID PFEA_PSEAE Reviewed; 746 AA.
AC Q05098;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Ferric enterobactin receptor;
DE Flags: Precursor;
GN Name=pfeA; OrderedLocusNames=PA2688;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K407;
RX PubMed=8419284; DOI=10.1128/jb.175.2.317-324.1993;
RA Dean C.R., Poole K.;
RT "Cloning and characterization of the ferric enterobactin receptor gene
RT (pfeA) of Pseudomonas aeruginosa.";
RL J. Bacteriol. 175:317-324(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Specific receptor for the siderophore ferric enterobactin.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- INDUCTION: By iron and enterobactin.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000305}.
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DR EMBL; M98033; AAA25928.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG06076.1; -; Genomic_DNA.
DR PIR; A40636; A40636.
DR RefSeq; NP_251378.1; NC_002516.2.
DR RefSeq; WP_003113404.1; NZ_QZGE01000008.1.
DR PDB; 5M9B; X-ray; 2.12 A; A=26-746.
DR PDB; 5MZS; X-ray; 2.67 A; A=26-746.
DR PDB; 5NC3; X-ray; 2.57 A; A=26-746.
DR PDB; 5NC4; X-ray; 2.80 A; A=26-746.
DR PDB; 5NR2; X-ray; 2.78 A; A=26-746.
DR PDB; 5OUT; X-ray; 2.90 A; A=26-746.
DR PDB; 6I2J; X-ray; 2.96 A; A=26-746.
DR PDB; 6Q5E; X-ray; 2.70 A; A=26-746.
DR PDB; 6R1F; X-ray; 3.11 A; A=26-746.
DR PDB; 6Y47; X-ray; 3.04 A; A=26-746.
DR PDB; 6YY5; X-ray; 2.72 A; AAA=26-746.
DR PDB; 6Z2N; X-ray; 3.03 A; AAA=26-746.
DR PDB; 6Z33; X-ray; 2.71 A; AAA=26-746.
DR PDB; 7OBW; X-ray; 2.66 A; AAA=26-746.
DR PDBsum; 5M9B; -.
DR PDBsum; 5MZS; -.
DR PDBsum; 5NC3; -.
DR PDBsum; 5NC4; -.
DR PDBsum; 5NR2; -.
DR PDBsum; 5OUT; -.
DR PDBsum; 6I2J; -.
DR PDBsum; 6Q5E; -.
DR PDBsum; 6R1F; -.
DR PDBsum; 6Y47; -.
DR PDBsum; 6YY5; -.
DR PDBsum; 6Z2N; -.
DR PDBsum; 6Z33; -.
DR PDBsum; 7OBW; -.
DR AlphaFoldDB; Q05098; -.
DR SMR; Q05098; -.
DR STRING; 287.DR97_5271; -.
DR TCDB; 1.B.14.1.5; the outer membrane receptor (omr) family.
DR PaxDb; Q05098; -.
DR PRIDE; Q05098; -.
DR EnsemblBacteria; AAG06076; AAG06076; PA2688.
DR GeneID; 882784; -.
DR KEGG; pae:PA2688; -.
DR PATRIC; fig|208964.12.peg.2813; -.
DR PseudoCAP; PA2688; -.
DR HOGENOM; CLU_008287_18_2_6; -.
DR InParanoid; Q05098; -.
DR OMA; NESGRTW; -.
DR PhylomeDB; Q05098; -.
DR BioCyc; PAER208964:G1FZ6-2728-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0019867; C:outer membrane; IDA:PseudoCAP.
DR GO; GO:0042912; F:colicin transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0042931; F:enterobactin transmembrane transporter activity; IMP:PseudoCAP.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IMP:PseudoCAP.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0042930; P:enterobactin transport; IMP:PseudoCAP.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR GO; GO:0015891; P:siderophore transport; IMP:PseudoCAP.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 1.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Ion transport; Iron; Iron transport;
KW Membrane; Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW Transmembrane beta strand; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..746
FT /note="Ferric enterobactin receptor"
FT /id="PRO_0000034769"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 39..44
FT /note="TonB box"
FT MOTIF 729..746
FT /note="TonB C-terminal box"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 45..48
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 55..59
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 60..65
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 69..71
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 73..76
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 82..85
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 87..90
FT /evidence="ECO:0007829|PDB:5NC3"
FT TURN 92..95
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 98..101
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 106..108
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 109..113
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:5OUT"
FT HELIX 120..123
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 137..141
FT /evidence="ECO:0007829|PDB:5NC3"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 146..153
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 154..160
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 165..173
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 181..193
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 199..225
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 230..236
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 242..244
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 254..267
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 272..286
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 292..294
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 298..303
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 309..323
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 328..343
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 345..348
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 349..351
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 357..359
FT /evidence="ECO:0007829|PDB:5NC3"
FT STRAND 361..380
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 382..400
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 402..405
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 410..412
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 420..422
FT /evidence="ECO:0007829|PDB:5NC3"
FT STRAND 425..443
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 446..457
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 458..460
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 461..475
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 478..489
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 493..496
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 501..506
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 516..519
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 527..540
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 543..560
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 565..567
FT /evidence="ECO:0007829|PDB:5M9B"
FT HELIX 573..575
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 579..603
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 606..620
FT /evidence="ECO:0007829|PDB:5M9B"
FT TURN 621..623
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 626..628
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 632..641
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 644..656
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 666..670
FT /evidence="ECO:0007829|PDB:5NC3"
FT HELIX 673..676
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 682..694
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 697..705
FT /evidence="ECO:0007829|PDB:5M9B"
FT STRAND 721..723
FT /evidence="ECO:0007829|PDB:6Y47"
FT STRAND 737..745
FT /evidence="ECO:0007829|PDB:5M9B"
SQ SEQUENCE 746 AA; 80968 MW; ADD4FB0CB22C3251 CRC64;
MSSRALPAVP FLLLSSCLLA NAVHAAGQGD GSVIELGEQT VVATAQEETK QAPGVSIITA
EDIAKRPPSN DLSQIIRTMP GVNLTGNSSS GQRGNNRQID IRGMGPENTL ILVDGKPVSS
RNSVRYGWRG ERDSRGDTNW VPADQVERIE VIRGPAAARY GNGAAGGVVN IITKQAGAET
HGNLSVYSNF PQHKAEGASE RMSFGLNGPL TENLSYRVYG NIAKTDSDDW DINAGHESNR
TGKQAGTLPA GREGVRNKDI DGLLSWRLTP EQTLEFEAGF SRQGNIYTGD TQNTNSNNYV
KQMLGHETNR MYRETYSVTH RGEWDFGSSL AYLQYEKTRN SRINEGLAGG TEGIFDPNNA
GFYTATLRDL TAHGEVNLPL HLGYEQTLTL GSEWTEQKLD DPSSNTQNTE EGGSIPGLAG
KNRSSSSSAR IFSLFAEDNI ELMPGTMLTP GLRWDHHDIV GDNWSPSLNL SHALTERVTL
KAGIARAYKA PNLYQLNPDY LLYSRGQGCY GQSTSCYLRG NDGLKAETSV NKELGIEYSH
DGLVAGLTYF RNDYKNKIES GLSPVDHASG GKGDYANAAI YQWENVPKAV VEGLEGTLTL
PLADGLKWSN NLTYMLQSKN KETGDVLSVT PRYTLNSMLD WQATDDLSLQ ATVTWYGKQK
PKKYDYHGDR VTGSANDQLS PYAIAGLGGT YRLSKNLSLG AGVDNLFDKR LFRAGNAQGV
VGIDGAGAAT YNEPGRTFYT SLTASF
