ID   PFER_PSEAE              Reviewed;         305 AA.
AC   Q04803;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Transcriptional activator protein PfeR;
GN   Name=pfeR; OrderedLocusNames=PA2686;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAO;
RX   PubMed=8361354; DOI=10.1111/j.1365-2958.1993.tb01654.x;
RA   Dean C.R., Poole K.;
RT   "Expression of the ferric enterobactin receptor (PfeA) of Pseudomonas
RT   aeruginosa: involvement of a two-component regulatory system.";
RL   Mol. Microbiol. 8:1095-1103(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Member of the two-component regulatory system PfeR/PfeS.
CC       Activates expression of the ferric enterobactin receptor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PfeS. {ECO:0000305}.
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DR   EMBL; L07739; AAA25929.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06074.1; -; Genomic_DNA.
DR   PIR; S34996; S34996.
DR   RefSeq; NP_251376.1; NC_002516.2.
DR   RefSeq; WP_010895629.1; NZ_QZGE01000008.1.
DR   AlphaFoldDB; Q04803; -.
DR   SMR; Q04803; -.
DR   STRING; 287.DR97_5273; -.
DR   PaxDb; Q04803; -.
DR   PRIDE; Q04803; -.
DR   DNASU; 882764; -.
DR   EnsemblBacteria; AAG06074; AAG06074; PA2686.
DR   GeneID; 882764; -.
DR   KEGG; pae:PA2686; -.
DR   PATRIC; fig|208964.12.peg.2811; -.
DR   PseudoCAP; PA2686; -.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   InParanoid; Q04803; -.
DR   OMA; RVRNQFP; -.
DR   PhylomeDB; Q04803; -.
DR   BioCyc; PAER208964:G1FZ6-2726-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IDA:PseudoCAP.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..305
FT                   /note="Transcriptional activator protein PfeR"
FT                   /id="PRO_0000081184"
FT   DOMAIN          79..192
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        200..301
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         128
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   305 AA;  34024 MW;  7B5F47DEF32A08E0 CRC64;
     MIVQPSAVAK GWPIATTLLP ASCGPADPKP EPKPKQRRLC RKVFPLRARC GALAHCPIPG
     KNEIFTNVNH SHISIPSPRL LLVEDDPRLR EDLDAHFRRR GFRVTVCGDG SHGLEAAGRE
     AFDLVLLDIM LPGLDGLALL ESLRREQATP VMLMSALGAE QDRISGFTRG ADDYLPKPFS
     LAELDARTDA LLRRVRLDRL PLAQRRDTRL VFDDQAQDVL HQGLPAGLTP SEYRLLATLR
     EHAGEALSKP FLYRSVLHRS YTRLDRGLDV HVCNLRRKLA VVAVRHLQIQ AVRGQGYLLV
     ETEHP