PFL5_SCHPO
ID PFL5_SCHPO Reviewed; 1283 AA.
AC Q9URU4; Q9USQ3;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Putative cell agglutination protein pfl5 {ECO:0000305};
DE AltName: Full=Adhesin pfl5 {ECO:0000303|PubMed:17870620};
DE AltName: Full=Pombe flocculin 5 {ECO:0000303|PubMed:23236291};
DE Flags: Precursor;
GN Name=pfl5 {ECO:0000303|PubMed:23236291};
GN ORFNames=SPBC1289.15 {ECO:0000312|PomBase:SPBC1289.15}, SPBC8E4.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP DOMAIN, AND REPEATS.
RX PubMed=17870620; DOI=10.1016/j.fgb.2007.08.002;
RA Linder T., Gustafsson C.M.;
RT "Molecular phylogenetics of ascomycotal adhesins--a novel family of
RT putative cell-surface adhesive proteins in fission yeasts.";
RL Fungal Genet. Biol. 45:485-497(2008).
RN [3]
RP FUNCTION.
RX PubMed=23236291; DOI=10.1371/journal.pgen.1003104;
RA Kwon E.J., Laderoute A., Chatfield-Reed K., Vachon L., Karagiannis J.,
RA Chua G.;
RT "Deciphering the transcriptional-regulatory network of flocculation in
RT Schizosaccharomyces pombe.";
RL PLoS Genet. 8:E1003104-E1003104(2012).
CC -!- FUNCTION: May be involved in agglutination during conjugation or other
CC aspects of colony formation (By similarity). Induces flocculation when
CC overexpressed (PubMed:23236291). {ECO:0000250|UniProtKB:O74346,
CC ECO:0000269|PubMed:23236291}.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mam3/map4 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB38695.1; -; Genomic_DNA.
DR PIR; T50375; T39174.
DR RefSeq; NP_596840.1; NM_001023861.2.
DR AlphaFoldDB; Q9URU4; -.
DR SMR; Q9URU4; -.
DR BioGRID; 276682; 3.
DR STRING; 4896.SPBC1289.15.1; -.
DR PaxDb; Q9URU4; -.
DR EnsemblFungi; SPBC1289.15.1; SPBC1289.15.1:pep; SPBC1289.15.
DR GeneID; 2540145; -.
DR KEGG; spo:SPBC1289.15; -.
DR PomBase; SPBC1289.15; pfl5.
DR VEuPathDB; FungiDB:SPBC1289.15; -.
DR HOGENOM; CLU_262920_0_0_1; -.
DR InParanoid; Q9URU4; -.
DR OMA; YKTIYGP; -.
DR PhylomeDB; Q9URU4; -.
DR PRO; PR:Q9URU4; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0000128; P:flocculation; IMP:PomBase.
DR InterPro; IPR018789; Flo11.
DR Pfam; PF10182; Flo11; 1.
DR SMART; SM01213; Flo11; 1.
DR PROSITE; PS51824; FLO11; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1283
FT /note="Putative cell agglutination protein pfl5"
FT /id="PRO_0000353810"
FT REPEAT 211..245
FT /note="1"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 246..280
FT /note="2"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 281..315
FT /note="3"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 316..350
FT /note="4"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 351..385
FT /note="5"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 386..420
FT /note="6"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 421..455
FT /note="7"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 456..490
FT /note="8"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 491..525
FT /note="9"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 526..560
FT /note="10"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 561..595
FT /note="11"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 596..630
FT /note="12"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 631..665
FT /note="13"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 666..700
FT /note="14"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 701..735
FT /note="15"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 736..770
FT /note="16"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 771..805
FT /note="17"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 806..840
FT /note="18"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 841..875
FT /note="19"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 876..910
FT /note="20"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 911..945
FT /note="21"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 946..980
FT /note="22"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 981..1015
FT /note="23"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 1016..1050
FT /note="24"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 1051..1085
FT /note="25"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 1086..1120
FT /note="26"
FT /evidence="ECO:0000305|PubMed:17870620"
FT DOMAIN 1118..1283
FT /note="Flo11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01168"
FT REGION 102..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..1120
FT /note="26 X 35 AA approximate tandem repeats"
FT /evidence="ECO:0000305|PubMed:17870620"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 336
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 406
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 546
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 686
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 721
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 1283 AA; 129532 MW; 0B8057CC41C82796 CRC64;
MLVFTDLIFL AIFAHIGKAT AKVWNRNVQG FLDLNLPNEC SQYTTIYSDG PSEYTSTLPY
THSFSNASVY TTLITITNSQ CTGNYSTLTI SSQPLIHTNT SISKPSQTAT PQNTNTTQVS
LTNGTTTNSY SNTNSLPITD TINGTTELII PTTSYNNQSH TLIYSTYTST YLPNSTIDLS
ILPHSTISTL STVSINDTSA SLSKTTSPTA GTITETIVSG SVGYTSTFPA SGTTSGTVEV
VEPTAGTITE TIVSGSVGYT STFPANGTTS GTVEVVEPTA GTITETIVSG SVGYTSTFPA
NGTTSGTVEV VEPTAGTITE TIVSGSVGYT STFPANGTTS GTVEVVEPTA GTVTETIVSG
SVGYTSTFPA SGTTSGTVEV VEPTAGTITE TIVSGSKAFT STFPANGTTS GTVEVVEPTA
GTITKTIVSG SKTFTSTFPA NGTTSGTVEV VEPTAGTITE TIVSGSVGYT STFPANGTTS
GTVEVVEPTA GTITETIVSG SKTFTSTFPA SGTTSGTVEV VEPTAGTITE TIVSGSKAFT
STFPANGTTS GTVEVVEPTA GTITETIVSG SVGYTSTFPA SGTTSGTVEV VEPTAGTVTE
TIVSGSVGYT STFPASGTTS GTVEVVEPTA GTVTETIVSG SVGYTSTFPA SGTTSGTVEV
VEPTAGTITE TIVSGSKAFT STFPANGTTS GTVEVVEPTA GTITETIVSG SKTFTSTFPA
NGTTSGTVEV VEPTAGTITE TIVSGSVGYT STFPASGTTS GTVEVVEPTA GTVTETVISG
SVSFMSTITA HDTSSGAVIV VEPTAGTVTE TIVSGSIPFT STIPAQGTTS GTVEVVEPTA
GTVTETIISG SVGYTSTFPA QGTTSGTVEV VEPTAGTVTE TIISGSVGYT STFPAQGTTS
GTVEIVAPTA GTVTETIVSG SIPFTSTIPA QGTTSGTVEV VEPTAGTVTE TIISGSVGYT
STFPAQGTTS GTVEIVAPTA GTVTETIVSG SIPFTSTIPA QGTTSGTVEV VEPTAGTVTE
TIISGSVGYT STFPAQGTTS GTVEVVEPTA GTVTETIVSG SIPFTSTIPA QGTTSGTVEI
VVPTAGTVTS TTGSGTSWFT TTVPATGTRS GSVIVVSPTA PACSSTPFAE CPNLNFNFHS
KNVNFPPADI RVISVTPKGN NMYDATVQFT TSSTMSKKSL SELKILGLSQ TYLLYSYNSK
VDNISNPGSW TSTVTVQGTS TGSYICMPHF QIQYDWCSAG VTDMSECNTW SYQKSYDYIT
GCNNYDNQGN SQTDASDYCW NVC
