PFL7_SCHPO
ID PFL7_SCHPO Reviewed; 358 AA.
AC Q9P5N1;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Putative cell-type specific agglutination protein pfl7 {ECO:0000305};
DE AltName: Full=Adhesin pfl7 {ECO:0000303|PubMed:17870620};
DE AltName: Full=Pombe flocculin 7 {ECO:0000303|PubMed:23236291};
DE Flags: Precursor;
GN Name=pfl7 {ECO:0000303|PubMed:23236291};
GN ORFNames=SPBC359.04c {ECO:0000312|PomBase:SPBC359.04c};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP DOMAIN, AND REPEATS.
RX PubMed=17870620; DOI=10.1016/j.fgb.2007.08.002;
RA Linder T., Gustafsson C.M.;
RT "Molecular phylogenetics of ascomycotal adhesins--a novel family of
RT putative cell-surface adhesive proteins in fission yeasts.";
RL Fungal Genet. Biol. 45:485-497(2008).
RN [3]
RP FUNCTION.
RX PubMed=23236291; DOI=10.1371/journal.pgen.1003104;
RA Kwon E.J., Laderoute A., Chatfield-Reed K., Vachon L., Karagiannis J.,
RA Chua G.;
RT "Deciphering the transcriptional-regulatory network of flocculation in
RT Schizosaccharomyces pombe.";
RL PLoS Genet. 8:E1003104-E1003104(2012).
CC -!- FUNCTION: May be involved in agglutination during conjugation or other
CC aspects of colony formation (By similarity). Induces flocculation when
CC overexpressed (PubMed:23236291). {ECO:0000250|UniProtKB:O74346,
CC ECO:0000269|PubMed:23236291}.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mam3/map4 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01169}.
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DR EMBL; CU329671; CAB91573.1; -; Genomic_DNA.
DR RefSeq; NP_595054.1; NM_001020960.2.
DR AlphaFoldDB; Q9P5N1; -.
DR BioGRID; 277451; 14.
DR STRING; 4896.SPBC359.04c.1; -.
DR PaxDb; Q9P5N1; -.
DR EnsemblFungi; SPBC359.04c.1; SPBC359.04c.1:pep; SPBC359.04c.
DR PomBase; SPBC359.04c; pfl7.
DR VEuPathDB; FungiDB:SPBC359.04c; -.
DR HOGENOM; CLU_774238_0_0_1; -.
DR PRO; PR:Q9P5N1; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0010339; C:external side of cell wall; TAS:PomBase.
DR GO; GO:0000128; P:flocculation; IMP:PomBase.
DR InterPro; IPR021746; DIPSY.
DR Pfam; PF11763; DIPSY; 1.
DR PROSITE; PS51825; DIPSY; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..358
FT /note="Putative cell-type specific agglutination protein
FT pfl7"
FT /id="PRO_0000353814"
FT REPEAT 148..180
FT /note="1"
FT /evidence="ECO:0000305|PubMed:17870620"
FT REPEAT 181..218
FT /note="2"
FT /evidence="ECO:0000305|PubMed:17870620"
FT DOMAIN 207..358
FT /note="DIPSY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01169"
FT REGION 90..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..218
FT /note="2 X 36 AA approximate tandem repeats"
FT /evidence="ECO:0000305|PubMed:17870620"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 245
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 305
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 358 AA; 37952 MW; B9EEF6FE1BE64F25 CRC64;
MNSLKSLCLK CIVTLCLLVN AFAFDYASLQ EQDENLLAAC PQYITIYTNG PVPGTTTIYP
TSNVASNTSE NYPYTGSKSL SSSSILSNST ISTSSSTPIT ASVPTSSSIL SNSTIPTTSP
VPTTSSTPTS SSILSNSTIP SSSSISASTI TTTIISGSTQ FTTTFVDQSI DTVEVVIPTA
GYITTTLTSG SSYPVSTTTL QTVSGTQSGL VEVITPSCGC NPENSFHLRL VGDSINPSYV
YKNTNVSDPD EGNMYTSTEG NTEAVNVFYY DPTVERILTC DCVRPVYTIY TDDPDSSFDI
IKNNNGTFTF VESSSGEIQT LHVSQYGALW ITSPEYDGET GGMDDVGFRA DDVILVAY
